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000157758 1001_ $$0P:(DE-2719)9000645$$aLiu, Peng$$b0$$eFirst author
000157758 245__ $$aThe organizational principles of de-differentiated topographic maps in somatosensory cortex.
000157758 260__ $$aCambridge$$beLife Sciences Publications$$c2021
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000157758 520__ $$aTopographic maps are a fundamental feature of cortex architecture in the mammalian brain. One common theory is that the de-differentiation of topographic maps links to impairments in everyday behavior due to less precise functional map readouts. Here, we tested this theory by characterizing de-differentiated topographic maps in primary somatosensory cortex (SI) of younger and older adults by means of ultra-high resolution functional magnetic resonance imaging together with perceptual finger individuation and hand motor performance. Older adults' SI maps showed similar amplitude and size to younger adults' maps, but presented with less representational similarity between distant fingers. Larger population receptive field sizes in older adults' maps did not correlate with behavior, whereas reduced cortical distances between D2 and D3 related to worse finger individuation but better motor performance. Our data uncover the drawbacks of a simple de-differentiation model of topographic map function, and motivate the introduction of feature-based models of cortical reorganization.
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000157758 650_7 $$2Other$$a7 Tesla MRI
000157758 650_7 $$2Other$$aaging
000157758 650_7 $$2Other$$ahuman
000157758 650_7 $$2Other$$aneuroscience
000157758 650_7 $$2Other$$apRF mapping
000157758 650_7 $$2Other$$asomatosensation
000157758 650_7 $$2Other$$asomatotopy
000157758 650_7 $$2Other$$atouch
000157758 650_2 $$2MeSH$$aAdult
000157758 650_2 $$2MeSH$$aAge Factors
000157758 650_2 $$2MeSH$$aBrain Mapping: instrumentation
000157758 650_2 $$2MeSH$$aBrain Mapping: methods
000157758 650_2 $$2MeSH$$aFemale
000157758 650_2 $$2MeSH$$aHand
000157758 650_2 $$2MeSH$$aHumans
000157758 650_2 $$2MeSH$$aMagnetic Resonance Imaging: methods
000157758 650_2 $$2MeSH$$aMale
000157758 650_2 $$2MeSH$$aPhysical Stimulation
000157758 650_2 $$2MeSH$$aSomatosensory Cortex: physiology
000157758 650_2 $$2MeSH$$aYoung Adult
000157758 7001_ $$0P:(DE-2719)9001858$$aChrysidou, Anastasia$$b1$$udzne
000157758 7001_ $$0P:(DE-2719)2812088$$aDöhler, Juliane$$b2
000157758 7001_ $$00000-0001-7257-428X$$aHebart, Martin N$$b3
000157758 7001_ $$0P:(DE-2719)2810583$$aWolbers, Thomas$$b4
000157758 7001_ $$0P:(DE-2719)9001179$$aKuehn, Esther$$b5$$eLast author
000157758 773__ $$0PERI:(DE-600)2687154-3$$a10.7554/eLife.60090$$gVol. 10, p. e60090$$pe60090$$teLife$$v10$$x2050-084X$$y2021
000157758 7870_ $$0DZNE-2022-01782$$aKuehn, Esther et.al.$$dDryad, 2020$$iRelatedTo$$r$$tThe organizational principles of de-differentiated topographic maps - Data
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