Journal Article

DZNE-2021-01215

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png The organizational principles of de-differentiated topographic maps in somatosensory cortex.

Liu, P. (First author)DZNE* ; Chrysidou, A.DZNE* ; Döhler, J.DZNE* ; Hebart, M. N. ; Wolbers, T.DZNE* ; Kuehn, E. (Last author)DZNE*

2021
eLife Sciences Publications Cambridge

This record in other databases:    

Please use a persistent id in citations: doi:10.7554/eLife.60090

Abstract: Topographic maps are a fundamental feature of cortex architecture in the mammalian brain. One common theory is that the de-differentiation of topographic maps links to impairments in everyday behavior due to less precise functional map readouts. Here, we tested this theory by characterizing de-differentiated topographic maps in primary somatosensory cortex (SI) of younger and older adults by means of ultra-high resolution functional magnetic resonance imaging together with perceptual finger individuation and hand motor performance. Older adults' SI maps showed similar amplitude and size to younger adults' maps, but presented with less representational similarity between distant fingers. Larger population receptive field sizes in older adults' maps did not correlate with behavior, whereas reduced cortical distances between D2 and D3 related to worse finger individuation but better motor performance. Our data uncover the drawbacks of a simple de-differentiation model of topographic map function, and motivate the introduction of feature-based models of cortical reorganization.

Keyword(s): Adult (MeSH) ; Age Factors (MeSH) ; Brain Mapping: instrumentation (MeSH) ; Brain Mapping: methods (MeSH) ; Female (MeSH) ; Hand (MeSH) ; Humans (MeSH) ; Magnetic Resonance Imaging: methods (MeSH) ; Male (MeSH) ; Physical Stimulation (MeSH) ; Somatosensory Cortex: physiology (MeSH) ; Young Adult (MeSH) ; 7 Tesla MRI ; aging ; human ; neuroscience ; pRF mapping ; somatosensation ; somatotopy ; touch

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Contributing Institute(s):

1. Aging, Cognition and Technology (AG Wolbers)
2. Clinical Neurophysiology and Memory (AG Düzel)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2021

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Database coverage:
; ; ; ; Article Processing Charges ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; DOAJ Seal ; Ebsco Academic Search ; Essential Science Indicators ; Fees ; IF >= 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection ; Zoological Record

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Linked articles:

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Dataset Kuehn, E.Extern* ; Liu, P.Extern* ; Chrysidou, A.Extern* ; Doehler, J. ; Wolbers, T. (Last author)DZNE*
Dataset: The organizational principles of de-differentiated topographic maps - Data
Dryad (2020) [10.5061/dryad.mgqnk98x8]2020 BibTeX | EndNote: XML, Text | RIS

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