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@ARTICLE{Liu:157758,
      author       = {Liu, Peng and Chrysidou, Anastasia and Döhler, Juliane and
                      Hebart, Martin N and Wolbers, Thomas and Kuehn, Esther},
      title        = {{T}he organizational principles of de-differentiated
                      topographic maps in somatosensory cortex.},
      journal      = {eLife},
      volume       = {10},
      issn         = {2050-084X},
      address      = {Cambridge},
      publisher    = {eLife Sciences Publications},
      reportid     = {DZNE-2021-01215},
      pages        = {e60090},
      year         = {2021},
      abstract     = {Topographic maps are a fundamental feature of cortex
                      architecture in the mammalian brain. One common theory is
                      that the de-differentiation of topographic maps links to
                      impairments in everyday behavior due to less precise
                      functional map readouts. Here, we tested this theory by
                      characterizing de-differentiated topographic maps in primary
                      somatosensory cortex (SI) of younger and older adults by
                      means of ultra-high resolution functional magnetic resonance
                      imaging together with perceptual finger individuation and
                      hand motor performance. Older adults' SI maps showed similar
                      amplitude and size to younger adults' maps, but presented
                      with less representational similarity between distant
                      fingers. Larger population receptive field sizes in older
                      adults' maps did not correlate with behavior, whereas
                      reduced cortical distances between D2 and D3 related to
                      worse finger individuation but better motor performance. Our
                      data uncover the drawbacks of a simple de-differentiation
                      model of topographic map function, and motivate the
                      introduction of feature-based models of cortical
                      reorganization.},
      keywords     = {Adult / Age Factors / Brain Mapping: instrumentation /
                      Brain Mapping: methods / Female / Hand / Humans / Magnetic
                      Resonance Imaging: methods / Male / Physical Stimulation /
                      Somatosensory Cortex: physiology / Young Adult / 7 Tesla MRI
                      (Other) / aging (Other) / human (Other) / neuroscience
                      (Other) / pRF mapping (Other) / somatosensation (Other) /
                      somatotopy (Other) / touch (Other)},
      cin          = {AG Wolbers / AG Düzel},
      ddc          = {600},
      cid          = {I:(DE-2719)1310002 / I:(DE-2719)5000006},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34003108},
      pmc          = {pmc:PMC8186903},
      doi          = {10.7554/eLife.60090},
      url          = {https://pub.dzne.de/record/157758},
}