000157766 001__ 157766
000157766 005__ 20240918142824.0
000157766 0247_ $$2doi$$a10.1073/pnas.2014784118
000157766 0247_ $$2pmid$$apmid:33782119
000157766 0247_ $$2pmc$$apmc:PMC8040628
000157766 0247_ $$2ISSN$$a0027-8424
000157766 0247_ $$2ISSN$$a1091-6490
000157766 0247_ $$2altmetric$$aaltmetric:102968726
000157766 037__ $$aDZNE-2021-01223
000157766 041__ $$aEnglish
000157766 082__ $$a500
000157766 1001_ $$0P:(DE-HGF)0$$aGraf, Jürgen$$b0
000157766 245__ $$aA limited role of NKCC1 in telencephalic glutamatergic neurons for developing hippocampal network dynamics and behavior.
000157766 260__ $$aWashington, DC$$bNational Acad. of Sciences$$c2021
000157766 3367_ $$2DRIVER$$aarticle
000157766 3367_ $$2DataCite$$aOutput Types/Journal article
000157766 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1726662447_11262
000157766 3367_ $$2BibTeX$$aARTICLE
000157766 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000157766 3367_ $$00$$2EndNote$$aJournal Article
000157766 520__ $$aNKCC1 is the primary transporter mediating chloride uptake in immature principal neurons, but its role in the development of in vivo network dynamics and cognitive abilities remains unknown. Here, we address the function of NKCC1 in developing mice using electrophysiological, optical, and behavioral approaches. We report that NKCC1 deletion from telencephalic glutamatergic neurons decreases in vitro excitatory actions of γ-aminobutyric acid (GABA) and impairs neuronal synchrony in neonatal hippocampal brain slices. In vivo, it has a minor impact on correlated spontaneous activity in the hippocampus and does not affect network activity in the intact visual cortex. Moreover, long-term effects of the developmental NKCC1 deletion on synaptic maturation, network dynamics, and behavioral performance are subtle. Our data reveal a neural network function of NKCC1 in hippocampal glutamatergic neurons in vivo, but challenge the hypothesis that NKCC1 is essential for major aspects of hippocampal development.
000157766 536__ $$0G:(DE-HGF)POF4-351$$a351 - Brain Function (POF4-351)$$cPOF4-351$$fPOF IV$$x0
000157766 588__ $$aDataset connected to CrossRef, PubMed, , Journals: pub.dzne.de
000157766 650_7 $$2Other$$aGABA
000157766 650_7 $$2Other$$aNKCC1
000157766 650_7 $$2Other$$adevelopment
000157766 650_7 $$2Other$$ahippocampus
000157766 650_7 $$2Other$$ain vivo
000157766 650_2 $$2MeSH$$aAnimals
000157766 650_2 $$2MeSH$$aAnimals, Newborn
000157766 650_2 $$2MeSH$$aGlutamic Acid: metabolism
000157766 650_2 $$2MeSH$$aHippocampus: growth & development
000157766 650_2 $$2MeSH$$aMice
000157766 650_2 $$2MeSH$$aNerve Net
000157766 650_2 $$2MeSH$$aNeurons: metabolism
000157766 650_2 $$2MeSH$$aSolute Carrier Family 12, Member 2: physiology
000157766 650_2 $$2MeSH$$aSynapses: metabolism
000157766 650_2 $$2MeSH$$aVisual Cortex: physiology
000157766 650_2 $$2MeSH$$agamma-Aminobutyric Acid: metabolism
000157766 7001_ $$0P:(DE-HGF)0$$aZhang, Chuanqiang$$b1
000157766 7001_ $$0P:(DE-2719)2811573$$aMarguet, Stephan$$b2$$udzne
000157766 7001_ $$aHerrmann, Tanja$$b3
000157766 7001_ $$0P:(DE-HGF)0$$aFlossmann, Tom$$b4
000157766 7001_ $$0P:(DE-2719)2811013$$aHinsch, Robin$$b5$$udzne
000157766 7001_ $$0P:(DE-HGF)0$$aRahmati, Vahid$$b6
000157766 7001_ $$aGuenther, Madlen$$b7
000157766 7001_ $$aFrahm, Christiane$$b8
000157766 7001_ $$0P:(DE-HGF)0$$aUrbach, Anja$$b9
000157766 7001_ $$0P:(DE-2719)2812485$$aNeves, Ricardo Melo$$b10$$udzne
000157766 7001_ $$0P:(DE-HGF)0$$aWitte, Otto W$$b11
000157766 7001_ $$0P:(DE-HGF)0$$aKiebel, Stefan J$$b12
000157766 7001_ $$0P:(DE-2719)2810976$$aIsbrandt, Dirk$$b13$$udzne
000157766 7001_ $$0P:(DE-HGF)0$$aHübner, Christian A$$b14
000157766 7001_ $$aHolthoff, Knut$$b15
000157766 7001_ $$0P:(DE-HGF)0$$aKirmse, Knut$$b16
000157766 773__ $$0PERI:(DE-600)1461794-8$$a10.1073/pnas.2014784118$$gVol. 118, no. 14, p. e2014784118 -$$n14$$pe2014784118$$tProceedings of the National Academy of Sciences of the United States of America$$v118$$x1091-6490$$y2021
000157766 8564_ $$uhttps://pub.dzne.de/record/157766/files/DZNE-2021-01223_Restricted.pdf
000157766 8564_ $$uhttps://pub.dzne.de/record/157766/files/DZNE-2021-01223_Restricted.pdf?subformat=pdfa$$xpdfa
000157766 909CO $$ooai:pub.dzne.de:157766$$pVDB
000157766 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811573$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b2$$kDZNE
000157766 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811013$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b5$$kDZNE
000157766 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812485$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b10$$kDZNE
000157766 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2810976$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b13$$kDZNE
000157766 9131_ $$0G:(DE-HGF)POF4-351$$1G:(DE-HGF)POF4-350$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lNeurodegenerative Diseases$$vBrain Function$$x0
000157766 9141_ $$y2021
000157766 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2021-01-29
000157766 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2021-01-29
000157766 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2021-01-29
000157766 915__ $$0StatID:(DE-HGF)0430$$2StatID$$aNational-Konsortium$$d2022-11-08$$wger
000157766 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2022-11-08
000157766 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2022-11-08
000157766 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2022-11-08
000157766 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2022-11-08
000157766 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2022-11-08
000157766 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2022-11-08
000157766 915__ $$0StatID:(DE-HGF)1040$$2StatID$$aDBCoverage$$bZoological Record$$d2022-11-08
000157766 915__ $$0StatID:(DE-HGF)1060$$2StatID$$aDBCoverage$$bCurrent Contents - Agriculture, Biology and Environmental Sciences$$d2022-11-08
000157766 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bP NATL ACAD SCI USA : 2021$$d2022-11-08
000157766 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2022-11-08
000157766 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2022-11-08
000157766 915__ $$0StatID:(DE-HGF)9910$$2StatID$$aIF >= 10$$bP NATL ACAD SCI USA : 2021$$d2022-11-08
000157766 9201_ $$0I:(DE-2719)1011003$$kAG Isbrandt$$lExperimental Neurophysiology$$x0
000157766 980__ $$ajournal
000157766 980__ $$aVDB
000157766 980__ $$aI:(DE-2719)1011003
000157766 980__ $$aUNRESTRICTED