Journal Article

DZNE-2021-01303

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Psychometric Properties of EQ-5D-3L and EQ-5D-5L in Cognitively Impaired Patients Living with Dementia.

Michalowsky, B. (First author)DZNE* ; Hoffmann, W.DZNE* ; Xie, F.

2021
IOS Press Amsterdam

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Please use a persistent id in citations: doi:10.3233/JAD-210421

Abstract: Assessing health-related quality of life in dementia poses challenges due to patients' cognitive impairment. It is unknown if the newly introduced EQ-5D five-level version (EQ-5D-5L) is superior to the 3-level version (EQ-5D-3L) in this cognitively impaired population group.To assess the psychometric properties of the EQ-5D-5L in comparison to the EQ-5D-3L in patients living with dementia (PwD).The EQ-5D-3L and EQ-5D-5L were assessed via interviews with n = 78 PwD at baseline and three and six months after, resulting in 131 assessments. The EQ-5D-3L and EQ-5D-5L were evaluated in terms of acceptability, agreement, ceiling effects, redistribution properties and inconsistency, informativity as well as convergent and discriminative validity.Mean index scores were higher for the EQ-5D-5L than the EQ-5D-3L (0.70 versus 0.64). Missing values occurred more frequently in the EQ-5D-5L than the EQ-5D-3L (8%versus 3%). Agreement between both measures was acceptable but poor in PwD with moderate to severe cognitive impairment. The index value's relative ceiling effect decreased from EQ-5D-3L to EQ-5D-5L by 17%. Inconsistency was moderate to high (13%). Absolute and relative informativity increased in the EQ-5D-5L compared to the 3L. The EQ-5D-5L demonstrated a lower discriminative ability and convergent validity, especially in PwD with moderate to severe cognitive deficits.The EQ-5D-5L was not superior as a self-rating instrument due to a lower acceptability and discriminative ability and a high inconsistency, especially in moderate to severe dementia. The EQ-5D-3L had slightly better psychometric properties and should preferably be used as a self-rating instrument in economic evaluations in dementia.

Keyword(s): Activities of Daily Living: psychology (MeSH) ; Aged, 80 and over (MeSH) ; Cognitive Dysfunction: psychology (MeSH) ; Dementia: psychology (MeSH) ; Female (MeSH) ; Health Status Indicators (MeSH) ; Humans (MeSH) ; Interviews as Topic (MeSH) ; Male (MeSH) ; Psychometrics: statistics & numerical data (MeSH) ; Quality of Life: psychology (MeSH) ; Reproducibility of Results (MeSH) ; Surveys and Questionnaires (MeSH) ; Alzheimer’s diseases ; EQ-5D ; dementia ; patient-reported outcomes ; preference-based measures ; quality of life ; validation

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Contributing Institute(s):

1. Translational Health Care Research (AG Hoffmann)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2021

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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