TY  - JOUR
AU  - Mauriello, Alessandro
AU  - Scimeca, Manuel
AU  - Amelio, Ivano
AU  - Massoud, Renato
AU  - Novelli, Antonio
AU  - Di Lorenzo, Francesca
AU  - Finocchiaro, Susanna
AU  - Cimino, Carolina
AU  - Telesca, Rossana
AU  - Chiocchi, Marcello
AU  - Sun, Qiang
AU  - Wang, Ying
AU  - Shi, Yufang
AU  - Novelli, Giuseppe
AU  - Melino, Gerry
TI  - Thromboembolism after COVID-19 vaccine in patients with preexisting thrombocytopenia.
JO  - Cell death & disease
VL  - 12
IS  - 8
SN  - 2041-4889
CY  - London [u.a.]
PB  - Nature Publishing Group
M1  - DZNE-2021-01403
SP  - 762
PY  - 2021
N1  - CC BY
AB  - While vaccination is the single most effective intervention to drastically reduce severe disease and death following SARS-CoV-2 infection, as shown in UK and Israel, some serious concerns have been raised for an unusual adverse drug reaction (ADR), including vaccine-induced immune thrombotic thrombocytopenia (VITT) with concurrent low platelets as well as capillary leak syndrome. In fact, the overall safety of the vaccine is highlighted by the low frequency of ADR considering that in UK, by the early June, 40 million first doses and 29 million second doses have been injected; nonetheless, 390 thrombotic events, including 71 fatal events have been reported. Interestingly, the cases reported low platelet counts with the presence of anti-platelet factor-4 (PF4) antibodies, indicating an abnormal clotting reaction. Here, out of three referred cases, we report a post-vaccine clinical case of fatal thrombosis with postmortem examination and whole exome sequencing (WES) analysis, whose pathogenesis appeared associated to a preexisting condition of thrombocytopenia due to myelodysplasia.
KW  - ChAdOx1 nCoV-19
KW  - Bone Marrow: pathology
KW  - COVID-19: prevention & control
KW  - COVID-19 Vaccines: adverse effects
KW  - Fatal Outcome
KW  - Female
KW  - Humans
KW  - Lung: pathology
KW  - Middle Aged
KW  - Myelodysplastic Syndromes: complications
KW  - Myelodysplastic Syndromes: diagnosis
KW  - Myelodysplastic Syndromes: pathology
KW  - SARS-CoV-2: immunology
KW  - Thrombocytopenia: complications
KW  - Thrombocytopenia: diagnosis
KW  - Thrombocytopenia: pathology
KW  - Thromboembolism: etiology
KW  - COVID-19 Vaccines (NLM Chemicals)
KW  - ChAdOx1 COVID-19 vaccine (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:34344867
C2  - pmc:PMC8328816
DO  - DOI:10.1038/s41419-021-04058-z
UR  - https://pub.dzne.de/record/162747
ER  -