Journal Article

DZNE-2021-01403

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Thromboembolism after COVID-19 vaccine in patients with preexisting thrombocytopenia.

Mauriello, A. ; Scimeca, M. ; Amelio, I. ; Massoud, R. ; Novelli, A. ; Di Lorenzo, F. ; Finocchiaro, S. ; Cimino, C. ; Telesca, R. ; Chiocchi, M. ; Sun, Q. ; Wang, Y. ; Shi, Y. ; Novelli, G. ; Melino, G. (Last author)DZNE*

2021
Nature Publishing Group London [u.a.]

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Please use a persistent id in citations: doi:10.1038/s41419-021-04058-z

Abstract: While vaccination is the single most effective intervention to drastically reduce severe disease and death following SARS-CoV-2 infection, as shown in UK and Israel, some serious concerns have been raised for an unusual adverse drug reaction (ADR), including vaccine-induced immune thrombotic thrombocytopenia (VITT) with concurrent low platelets as well as capillary leak syndrome. In fact, the overall safety of the vaccine is highlighted by the low frequency of ADR considering that in UK, by the early June, 40 million first doses and 29 million second doses have been injected; nonetheless, 390 thrombotic events, including 71 fatal events have been reported. Interestingly, the cases reported low platelet counts with the presence of anti-platelet factor-4 (PF4) antibodies, indicating an abnormal clotting reaction. Here, out of three referred cases, we report a post-vaccine clinical case of fatal thrombosis with postmortem examination and whole exome sequencing (WES) analysis, whose pathogenesis appeared associated to a preexisting condition of thrombocytopenia due to myelodysplasia.

Keyword(s): ChAdOx1 nCoV-19 (MeSH) ; Bone Marrow: pathology (MeSH) ; COVID-19: prevention & control (MeSH) ; COVID-19 Vaccines: adverse effects (MeSH) ; Fatal Outcome (MeSH) ; Female (MeSH) ; Humans (MeSH) ; Lung: pathology (MeSH) ; Middle Aged (MeSH) ; Myelodysplastic Syndromes: complications (MeSH) ; Myelodysplastic Syndromes: diagnosis (MeSH) ; Myelodysplastic Syndromes: pathology (MeSH) ; SARS-CoV-2: immunology (MeSH) ; Thrombocytopenia: complications (MeSH) ; Thrombocytopenia: diagnosis (MeSH) ; Thrombocytopenia: pathology (MeSH) ; Thromboembolism: etiology (MeSH) ; COVID-19 Vaccines ; ChAdOx1 COVID-19 vaccine

Note: CC BY

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Contributing Institute(s):

1. Synaptic Connectivity and Neurodegeneration (AG Nicotera)

Research Program(s):

1. 351 - Brain Function (POF4-351) (POF4-351)

Appears in the scientific report 2021

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