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000162846 1001_ $$aSchinke, Christian$$b0
000162846 245__ $$aDataset for: Modeling chemotherapy induced neurotoxicity with human induced pluripotent stem cell (iPSC)-derived sensory neurons.
000162846 260__ $$aAmsterdam [u.a.]$$bElsevier$$c2021
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000162846 520__ $$aChemotherapy-induced peripheral neuropathy (CIPN) is a frequent and potentially irreversible adverse event of cytotoxic chemotherapy. We evaluate whether sensory neurons derived from induced pluripotent stem cells (iPSC-DSN) can serve as human disease model system for chemotherapy induced neurotoxicity. Sensory neurons differentiated from two established induced pluripotent stem cell lines were used (s.c. BIHi005-A https://hpscreg.eu/cell-line/BIHi005-A and BIHi004-B https://hpscreg.eu/cell-line/BIHi004-B, Berlin Institute of Health Stem Cell Core Facility). Cell viability and cytotoxicity assays were performed, comparing susceptibility to four neurotoxic and two non-neurotoxic drugs. RNA sequencing analyses in paclitaxel vs. vehicle (DMSO)-treated sensory neurons were performed. Treatment of iPSC-DSN for 24 h with the neurotoxic drugs paclitaxel, bortezomib, vincristine and cisplatin led to a dose dependent decline of cell viability in clinically relevant IC50 ranges, which was not the case for the non-neurotoxic compounds doxorubicin and 5-fluorouracil. RNA sequencing analyses at 24 h, i.e. before paclitaxel-induced cell death occurred, revealed the differential expression of genes of neuronal injury, cellular stress response, and sterol pathways in response to 1 µM paclitaxel. Neuroprotective effects of lithium chloride co-incubation, which were previously shown in rodent dorsal root ganglia, could be replicated in human iPSC-DSN. Cell lines from the two different donors BIHi005-A and BIHi004-B showed different responses to the neurotoxic treatment in cell viability and cytotoxicity assays.
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000162846 650_7 $$2Other$$aChemotherapy induced neuropathy
000162846 650_7 $$2Other$$aInduced pluripotent stem cell derived sensory neurons (iPSC-DSN)
000162846 650_7 $$2Other$$aLithium
000162846 650_7 $$2Other$$aReplacement
000162846 650_7 $$2Other$$aTranscriptome
000162846 7001_ $$aFernandez Vallone, Valeria$$b1
000162846 7001_ $$aIvanov, Andranik$$b2
000162846 7001_ $$aPeng, Yangfan$$b3
000162846 7001_ $$0P:(DE-2719)2812030$$aKörtvelyessy, Péter$$b4$$udzne
000162846 7001_ $$aNolte, Luca$$b5
000162846 7001_ $$aHuehnchen, Petra$$b6
000162846 7001_ $$aBeule, Dieter$$b7
000162846 7001_ $$aStachelscheid, Harald$$b8
000162846 7001_ $$aBoehmerle, Wolfgang$$b9
000162846 7001_ $$0P:(DE-2719)2811033$$aEndres, Matthias$$b10$$eLast author$$udzne
000162846 773__ $$0PERI:(DE-600)2786545-9$$a10.1016/j.dib.2021.107320$$gVol. 38, p. 107320 -$$p107320$$tData in Brief$$v38$$x2352-3409$$y2021
000162846 7870_ $$0DZNE-2021-00442$$aSchinke, Christian et.al.$$dOrlando, Fla. : Academic Press, 2021$$iRelatedTo$$r$$tModeling chemotherapy induced neurotoxicity with human induced pluripotent stem cell (iPSC) -derived sensory neurons.
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