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@ARTICLE{Schinke:162846,
      author       = {Schinke, Christian and Fernandez Vallone, Valeria and
                      Ivanov, Andranik and Peng, Yangfan and Körtvelyessy, Péter
                      and Nolte, Luca and Huehnchen, Petra and Beule, Dieter and
                      Stachelscheid, Harald and Boehmerle, Wolfgang and Endres,
                      Matthias},
      title        = {{D}ataset for: {M}odeling chemotherapy induced
                      neurotoxicity with human induced pluripotent stem cell
                      (i{PSC})-derived sensory neurons.},
      journal      = {Data in Brief},
      volume       = {38},
      issn         = {2352-3409},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {DZNE-2021-01501},
      pages        = {107320},
      year         = {2021},
      note         = {(CC BY-NC-ND)},
      abstract     = {Chemotherapy-induced peripheral neuropathy (CIPN) is a
                      frequent and potentially irreversible adverse event of
                      cytotoxic chemotherapy. We evaluate whether sensory neurons
                      derived from induced pluripotent stem cells (iPSC-DSN) can
                      serve as human disease model system for chemotherapy induced
                      neurotoxicity. Sensory neurons differentiated from two
                      established induced pluripotent stem cell lines were used
                      (s.c. BIHi005-A https://hpscreg.eu/cell-line/BIHi005-A and
                      BIHi004-B https://hpscreg.eu/cell-line/BIHi004-B, Berlin
                      Institute of Health Stem Cell Core Facility). Cell viability
                      and cytotoxicity assays were performed, comparing
                      susceptibility to four neurotoxic and two non-neurotoxic
                      drugs. RNA sequencing analyses in paclitaxel vs. vehicle
                      (DMSO)-treated sensory neurons were performed. Treatment of
                      iPSC-DSN for 24 h with the neurotoxic drugs paclitaxel,
                      bortezomib, vincristine and cisplatin led to a dose
                      dependent decline of cell viability in clinically relevant
                      IC50 ranges, which was not the case for the non-neurotoxic
                      compounds doxorubicin and 5-fluorouracil. RNA sequencing
                      analyses at 24 h, i.e. before paclitaxel-induced cell death
                      occurred, revealed the differential expression of genes of
                      neuronal injury, cellular stress response, and sterol
                      pathways in response to 1 µM paclitaxel. Neuroprotective
                      effects of lithium chloride co-incubation, which were
                      previously shown in rodent dorsal root ganglia, could be
                      replicated in human iPSC-DSN. Cell lines from the two
                      different donors BIHi005-A and BIHi004-B showed different
                      responses to the neurotoxic treatment in cell viability and
                      cytotoxicity assays.},
      keywords     = {3R (Other) / Chemotherapy induced neuropathy (Other) /
                      Induced pluripotent stem cell derived sensory neurons
                      (iPSC-DSN) (Other) / Lithium (Other) / Replacement (Other) /
                      Transcriptome (Other)},
      cin          = {AG Endres / AG Düzel},
      ddc          = {570},
      cid          = {I:(DE-2719)1811005 / I:(DE-2719)5000006},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34485650},
      pmc          = {pmc:PMC8408513},
      doi          = {10.1016/j.dib.2021.107320},
      url          = {https://pub.dzne.de/record/162846},
}