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| 001 | 162846 | ||
| 005 | 20240208114853.0 | ||
| 024 | 7 | _ | |a 10.1016/j.dib.2021.107320 |2 doi |
| 024 | 7 | _ | |a pmid:34485650 |2 pmid |
| 024 | 7 | _ | |a pmc:PMC8408513 |2 pmc |
| 024 | 7 | _ | |a altmetric:112990302 |2 altmetric |
| 037 | _ | _ | |a DZNE-2021-01501 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 570 |
| 100 | 1 | _ | |a Schinke, Christian |b 0 |
| 245 | _ | _ | |a Dataset for: Modeling chemotherapy induced neurotoxicity with human induced pluripotent stem cell (iPSC)-derived sensory neurons. |
| 260 | _ | _ | |a Amsterdam [u.a.] |c 2021 |b Elsevier |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1707312923_6692 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a (CC BY-NC-ND) |
| 520 | _ | _ | |a Chemotherapy-induced peripheral neuropathy (CIPN) is a frequent and potentially irreversible adverse event of cytotoxic chemotherapy. We evaluate whether sensory neurons derived from induced pluripotent stem cells (iPSC-DSN) can serve as human disease model system for chemotherapy induced neurotoxicity. Sensory neurons differentiated from two established induced pluripotent stem cell lines were used (s.c. BIHi005-A https://hpscreg.eu/cell-line/BIHi005-A and BIHi004-B https://hpscreg.eu/cell-line/BIHi004-B, Berlin Institute of Health Stem Cell Core Facility). Cell viability and cytotoxicity assays were performed, comparing susceptibility to four neurotoxic and two non-neurotoxic drugs. RNA sequencing analyses in paclitaxel vs. vehicle (DMSO)-treated sensory neurons were performed. Treatment of iPSC-DSN for 24 h with the neurotoxic drugs paclitaxel, bortezomib, vincristine and cisplatin led to a dose dependent decline of cell viability in clinically relevant IC50 ranges, which was not the case for the non-neurotoxic compounds doxorubicin and 5-fluorouracil. RNA sequencing analyses at 24 h, i.e. before paclitaxel-induced cell death occurred, revealed the differential expression of genes of neuronal injury, cellular stress response, and sterol pathways in response to 1 µM paclitaxel. Neuroprotective effects of lithium chloride co-incubation, which were previously shown in rodent dorsal root ganglia, could be replicated in human iPSC-DSN. Cell lines from the two different donors BIHi005-A and BIHi004-B showed different responses to the neurotoxic treatment in cell viability and cytotoxicity assays. |
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| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de |
| 650 | _ | 7 | |a 3R |2 Other |
| 650 | _ | 7 | |a Chemotherapy induced neuropathy |2 Other |
| 650 | _ | 7 | |a Induced pluripotent stem cell derived sensory neurons (iPSC-DSN) |2 Other |
| 650 | _ | 7 | |a Lithium |2 Other |
| 650 | _ | 7 | |a Replacement |2 Other |
| 650 | _ | 7 | |a Transcriptome |2 Other |
| 700 | 1 | _ | |a Fernandez Vallone, Valeria |b 1 |
| 700 | 1 | _ | |a Ivanov, Andranik |b 2 |
| 700 | 1 | _ | |a Peng, Yangfan |b 3 |
| 700 | 1 | _ | |a Körtvelyessy, Péter |0 P:(DE-2719)2812030 |b 4 |u dzne |
| 700 | 1 | _ | |a Nolte, Luca |b 5 |
| 700 | 1 | _ | |a Huehnchen, Petra |b 6 |
| 700 | 1 | _ | |a Beule, Dieter |b 7 |
| 700 | 1 | _ | |a Stachelscheid, Harald |b 8 |
| 700 | 1 | _ | |a Boehmerle, Wolfgang |b 9 |
| 700 | 1 | _ | |a Endres, Matthias |0 P:(DE-2719)2811033 |b 10 |e Last author |u dzne |
| 773 | _ | _ | |a 10.1016/j.dib.2021.107320 |g Vol. 38, p. 107320 - |0 PERI:(DE-600)2786545-9 |p 107320 |t Data in Brief |v 38 |y 2021 |x 2352-3409 |
| 787 | 0 | _ | |a Schinke, Christian et.al. |d Orlando, Fla. : Academic Press, 2021 |i RelatedTo |0 DZNE-2021-00442 |r |t Modeling chemotherapy induced neurotoxicity with human induced pluripotent stem cell (iPSC) -derived sensory neurons. |
| 856 | 4 | _ | |u https://pub.dzne.de/record/162846/files/DZNE-2021-01501.pdf |y OpenAccess |
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