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000162892 041__ $$aEnglish
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000162892 1001_ $$00000-0001-5047-5205$$aHeinrichs, Hannah S$$b0
000162892 245__ $$aEffects of bariatric surgery on functional connectivity of the reward and default mode network: A pre-registered analysis.
000162892 260__ $$aNew York, NY$$bWiley-Liss$$c2021
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000162892 520__ $$aObesity imposes serious health risks and involves alterations in resting-state functional connectivity of brain networks involved in eating behavior. Bariatric surgery is an effective treatment, but its effects on functional connectivity are still under debate. In this pre-registered study, we aimed to determine the effects of bariatric surgery on major resting-state brain networks (reward and default mode network) in a longitudinal controlled design. Thirty-three bariatric surgery patients and 15 obese waiting-list control patients underwent magnetic resonance imaging at baseline, after 6 and 12 months. We conducted a pre-registered whole-brain time-by-group interaction analysis, and a time-by-group interaction analysis on within-network connectivity. In exploratory analyses, we investigated the effects of weight loss and head motion. Bariatric surgery compared to waiting did not significantly affect functional connectivity of the reward network and the default mode network (FWE-corrected p > .05), neither whole-brain nor within-network. In exploratory analyses, surgery-related BMI decrease (FWE-corrected p = .041) and higher average head motion (FWE-corrected p = .021) resulted in significantly stronger connectivity of the reward network with medial posterior frontal regions. This pre-registered well-controlled study did not support a strong effect of bariatric surgery, compared to waiting, on major resting-state brain networks after 6 months. Exploratory analyses indicated that head motion might have confounded the effects. Data pooling and more rigorous control of within-scanner head motion during data acquisition are needed to substantiate effects of bariatric surgery on brain organization.
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000162892 650_7 $$2Other$$abariatric surgery
000162892 650_7 $$2Other$$adefault mode network
000162892 650_7 $$2Other$$ahead motion
000162892 650_7 $$2Other$$ahumans
000162892 650_7 $$2Other$$alongitudinal
000162892 650_7 $$2Other$$amagnetic resonance imaging
000162892 650_7 $$2Other$$aobesity
000162892 650_7 $$2Other$$areward
000162892 650_7 $$2Other$$awaiting list
000162892 650_7 $$2Other$$aweight loss
000162892 650_2 $$2MeSH$$aAdult
000162892 650_2 $$2MeSH$$aBariatric Surgery
000162892 650_2 $$2MeSH$$aBrain: diagnostic imaging
000162892 650_2 $$2MeSH$$aBrain: physiopathology
000162892 650_2 $$2MeSH$$aConnectome
000162892 650_2 $$2MeSH$$aDefault Mode Network: diagnostic imaging
000162892 650_2 $$2MeSH$$aDefault Mode Network: physiopathology
000162892 650_2 $$2MeSH$$aFemale
000162892 650_2 $$2MeSH$$aHumans
000162892 650_2 $$2MeSH$$aLongitudinal Studies
000162892 650_2 $$2MeSH$$aMagnetic Resonance Imaging
000162892 650_2 $$2MeSH$$aMale
000162892 650_2 $$2MeSH$$aMiddle Aged
000162892 650_2 $$2MeSH$$aNerve Net: diagnostic imaging
000162892 650_2 $$2MeSH$$aNerve Net: physiopathology
000162892 650_2 $$2MeSH$$aObesity, Morbid: diagnostic imaging
000162892 650_2 $$2MeSH$$aObesity, Morbid: physiopathology
000162892 650_2 $$2MeSH$$aObesity, Morbid: surgery
000162892 650_2 $$2MeSH$$aOutcome Assessment, Health Care
000162892 650_2 $$2MeSH$$aReward
000162892 7001_ $$00000-0001-5401-852X$$aBeyer, Frauke$$b1
000162892 7001_ $$00000-0001-5011-8275$$aMedawar, Evelyn$$b2
000162892 7001_ $$00000-0002-0656-5323$$aPrehn, Kristin$$b3
000162892 7001_ $$aOrdemann, Jürgen$$b4
000162892 7001_ $$0P:(DE-2719)2812683$$aFlöel, Agnes$$b5$$udzne
000162892 7001_ $$00000-0001-9054-6688$$aWitte, A Veronica$$b6
000162892 773__ $$0PERI:(DE-600)1492703-2$$a10.1002/hbm.25624$$gVol. 42, no. 16, p. 5357 - 5373$$n16$$p5357 - 5373$$tHuman brain mapping$$v42$$x1097-0193$$y2021
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