Journal Article

DZNE-2021-01547

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Effects of bariatric surgery on functional connectivity of the reward and default mode network: A pre-registered analysis.

Heinrichs, H. S. ; Beyer, F. ; Medawar, E. ; Prehn, K. ; Ordemann, J. ; Flöel, A.DZNE* ; Witte, A. V.

2021
Wiley-Liss New York, NY

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Please use a persistent id in citations: doi:10.1002/hbm.25624

Abstract: Obesity imposes serious health risks and involves alterations in resting-state functional connectivity of brain networks involved in eating behavior. Bariatric surgery is an effective treatment, but its effects on functional connectivity are still under debate. In this pre-registered study, we aimed to determine the effects of bariatric surgery on major resting-state brain networks (reward and default mode network) in a longitudinal controlled design. Thirty-three bariatric surgery patients and 15 obese waiting-list control patients underwent magnetic resonance imaging at baseline, after 6 and 12 months. We conducted a pre-registered whole-brain time-by-group interaction analysis, and a time-by-group interaction analysis on within-network connectivity. In exploratory analyses, we investigated the effects of weight loss and head motion. Bariatric surgery compared to waiting did not significantly affect functional connectivity of the reward network and the default mode network (FWE-corrected p > .05), neither whole-brain nor within-network. In exploratory analyses, surgery-related BMI decrease (FWE-corrected p = .041) and higher average head motion (FWE-corrected p = .021) resulted in significantly stronger connectivity of the reward network with medial posterior frontal regions. This pre-registered well-controlled study did not support a strong effect of bariatric surgery, compared to waiting, on major resting-state brain networks after 6 months. Exploratory analyses indicated that head motion might have confounded the effects. Data pooling and more rigorous control of within-scanner head motion during data acquisition are needed to substantiate effects of bariatric surgery on brain organization.

Keyword(s): Adult (MeSH) ; Bariatric Surgery (MeSH) ; Brain: diagnostic imaging (MeSH) ; Brain: physiopathology (MeSH) ; Connectome (MeSH) ; Default Mode Network: diagnostic imaging (MeSH) ; Default Mode Network: physiopathology (MeSH) ; Female (MeSH) ; Humans (MeSH) ; Longitudinal Studies (MeSH) ; Magnetic Resonance Imaging (MeSH) ; Male (MeSH) ; Middle Aged (MeSH) ; Nerve Net: diagnostic imaging (MeSH) ; Nerve Net: physiopathology (MeSH) ; Obesity, Morbid: diagnostic imaging (MeSH) ; Obesity, Morbid: physiopathology (MeSH) ; Obesity, Morbid: surgery (MeSH) ; Outcome Assessment, Health Care (MeSH) ; Reward (MeSH) ; bariatric surgery ; default mode network ; head motion ; humans ; longitudinal ; magnetic resonance imaging ; obesity ; reward ; waiting list ; weight loss

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Contributing Institute(s):

1. Clinical Dementia Research (Rostock /Greifswald) (AG Teipel)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2021

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Database coverage:
; ; ; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DEAL Wiley ; DOAJ Seal ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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