TY  - JOUR
AU  - Heinrichs, Hannah S
AU  - Beyer, Frauke
AU  - Medawar, Evelyn
AU  - Prehn, Kristin
AU  - Ordemann, Jürgen
AU  - Flöel, Agnes
AU  - Witte, A Veronica
TI  - Effects of bariatric surgery on functional connectivity of the reward and default mode network: A pre-registered analysis.
JO  - Human brain mapping
VL  - 42
IS  - 16
SN  - 1097-0193
CY  - New York, NY
PB  - Wiley-Liss
M1  - DZNE-2021-01547
SP  - 5357 - 5373
PY  - 2021
AB  - Obesity imposes serious health risks and involves alterations in resting-state functional connectivity of brain networks involved in eating behavior. Bariatric surgery is an effective treatment, but its effects on functional connectivity are still under debate. In this pre-registered study, we aimed to determine the effects of bariatric surgery on major resting-state brain networks (reward and default mode network) in a longitudinal controlled design. Thirty-three bariatric surgery patients and 15 obese waiting-list control patients underwent magnetic resonance imaging at baseline, after 6 and 12 months. We conducted a pre-registered whole-brain time-by-group interaction analysis, and a time-by-group interaction analysis on within-network connectivity. In exploratory analyses, we investigated the effects of weight loss and head motion. Bariatric surgery compared to waiting did not significantly affect functional connectivity of the reward network and the default mode network (FWE-corrected p > .05), neither whole-brain nor within-network. In exploratory analyses, surgery-related BMI decrease (FWE-corrected p = .041) and higher average head motion (FWE-corrected p = .021) resulted in significantly stronger connectivity of the reward network with medial posterior frontal regions. This pre-registered well-controlled study did not support a strong effect of bariatric surgery, compared to waiting, on major resting-state brain networks after 6 months. Exploratory analyses indicated that head motion might have confounded the effects. Data pooling and more rigorous control of within-scanner head motion during data acquisition are needed to substantiate effects of bariatric surgery on brain organization.
KW  - Adult
KW  - Bariatric Surgery
KW  - Brain: diagnostic imaging
KW  - Brain: physiopathology
KW  - Connectome
KW  - Default Mode Network: diagnostic imaging
KW  - Default Mode Network: physiopathology
KW  - Female
KW  - Humans
KW  - Longitudinal Studies
KW  - Magnetic Resonance Imaging
KW  - Male
KW  - Middle Aged
KW  - Nerve Net: diagnostic imaging
KW  - Nerve Net: physiopathology
KW  - Obesity, Morbid: diagnostic imaging
KW  - Obesity, Morbid: physiopathology
KW  - Obesity, Morbid: surgery
KW  - Outcome Assessment, Health Care
KW  - Reward
KW  - bariatric surgery (Other)
KW  - default mode network (Other)
KW  - head motion (Other)
KW  - humans (Other)
KW  - longitudinal (Other)
KW  - magnetic resonance imaging (Other)
KW  - obesity (Other)
KW  - reward (Other)
KW  - waiting list (Other)
KW  - weight loss (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:34432350
C2  - pmc:PMC8519880
DO  - DOI:10.1002/hbm.25624
UR  - https://pub.dzne.de/record/162892
ER  -