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@ARTICLE{Heinrichs:162892,
      author       = {Heinrichs, Hannah S and Beyer, Frauke and Medawar, Evelyn
                      and Prehn, Kristin and Ordemann, Jürgen and Flöel, Agnes
                      and Witte, A Veronica},
      title        = {{E}ffects of bariatric surgery on functional connectivity
                      of the reward and default mode network: {A} pre-registered
                      analysis.},
      journal      = {Human brain mapping},
      volume       = {42},
      number       = {16},
      issn         = {1097-0193},
      address      = {New York, NY},
      publisher    = {Wiley-Liss},
      reportid     = {DZNE-2021-01547},
      pages        = {5357 - 5373},
      year         = {2021},
      abstract     = {Obesity imposes serious health risks and involves
                      alterations in resting-state functional connectivity of
                      brain networks involved in eating behavior. Bariatric
                      surgery is an effective treatment, but its effects on
                      functional connectivity are still under debate. In this
                      pre-registered study, we aimed to determine the effects of
                      bariatric surgery on major resting-state brain networks
                      (reward and default mode network) in a longitudinal
                      controlled design. Thirty-three bariatric surgery patients
                      and 15 obese waiting-list control patients underwent
                      magnetic resonance imaging at baseline, after 6 and
                      12 months. We conducted a pre-registered whole-brain
                      time-by-group interaction analysis, and a time-by-group
                      interaction analysis on within-network connectivity. In
                      exploratory analyses, we investigated the effects of weight
                      loss and head motion. Bariatric surgery compared to waiting
                      did not significantly affect functional connectivity of the
                      reward network and the default mode network (FWE-corrected p
                      > .05), neither whole-brain nor within-network. In
                      exploratory analyses, surgery-related BMI decrease
                      (FWE-corrected p = .041) and higher average head motion
                      (FWE-corrected p = .021) resulted in significantly
                      stronger connectivity of the reward network with medial
                      posterior frontal regions. This pre-registered
                      well-controlled study did not support a strong effect of
                      bariatric surgery, compared to waiting, on major
                      resting-state brain networks after 6 months. Exploratory
                      analyses indicated that head motion might have confounded
                      the effects. Data pooling and more rigorous control of
                      within-scanner head motion during data acquisition are
                      needed to substantiate effects of bariatric surgery on brain
                      organization.},
      keywords     = {Adult / Bariatric Surgery / Brain: diagnostic imaging /
                      Brain: physiopathology / Connectome / Default Mode Network:
                      diagnostic imaging / Default Mode Network: physiopathology /
                      Female / Humans / Longitudinal Studies / Magnetic Resonance
                      Imaging / Male / Middle Aged / Nerve Net: diagnostic imaging
                      / Nerve Net: physiopathology / Obesity, Morbid: diagnostic
                      imaging / Obesity, Morbid: physiopathology / Obesity,
                      Morbid: surgery / Outcome Assessment, Health Care / Reward /
                      bariatric surgery (Other) / default mode network (Other) /
                      head motion (Other) / humans (Other) / longitudinal (Other)
                      / magnetic resonance imaging (Other) / obesity (Other) /
                      reward (Other) / waiting list (Other) / weight loss (Other)},
      cin          = {AG Teipel},
      ddc          = {610},
      cid          = {I:(DE-2719)1510100},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34432350},
      pmc          = {pmc:PMC8519880},
      doi          = {10.1002/hbm.25624},
      url          = {https://pub.dzne.de/record/162892},
}