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000163295 1001_ $$0P:(DE-2719)9001081$$aHeumueller, Stefanie-Elisabeth$$b0$$eFirst author$$udzne
000163295 245__ $$aPropagation and Dissemination Strategies of Transmissible Spongiform Encephalopathy Agents in Mammalian Cells
000163295 260__ $$aBasel$$bMolecular Diversity Preservation International$$c2022
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000163295 520__ $$aTransmissible spongiform encephalopathies or prion disorders are fatal infectious diseases that cause characteristic spongiform degeneration in the central nervous system. The causative agent, the so-called prion, is an unconventional infectious agent that propagates by converting the host-encoded cellular prion protein PrP into ordered protein aggregates with infectious properties. Prions are devoid of coding nucleic acid and thus rely on the host cell machinery for propagation. While it is now established that, in addition to PrP, other cellular factors or processes determine the susceptibility of cell lines to prion infection, exact factors and cellular processes remain broadly obscure. Still, cellular models have uncovered important aspects of prion propagation and revealed intercellular dissemination strategies shared with other intracellular pathogens. Here, we summarize what we learned about the processes of prion invasion, intracellular replication and subsequent dissemination from ex vivo cell models. View Full-Text
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000163295 650_2 $$2MeSH$$aAnimals
000163295 650_2 $$2MeSH$$aCentral Nervous System: metabolism
000163295 650_2 $$2MeSH$$aMammals: metabolism
000163295 650_2 $$2MeSH$$aPrion Diseases: metabolism
000163295 650_2 $$2MeSH$$aPrion Proteins
000163295 650_2 $$2MeSH$$aPrions: metabolism
000163295 7001_ $$0P:(DE-2719)2812579$$aHornberger, Annika C.$$b1$$udzne
000163295 7001_ $$0P:(DE-2719)9001960$$aHebestreit, Alina$$b2$$udzne
000163295 7001_ $$0P:(DE-2719)2810581$$aHossinger, André$$b3$$udzne
000163295 7001_ $$0P:(DE-2719)2481765$$aVorberg, Ina$$b4$$eLast author$$udzne
000163295 773__ $$0PERI:(DE-600)2019364-6$$a10.3390/ijms23062909$$gVol. 23, no. 6, p. 2909 -$$n6$$p2909$$tInternational journal of molecular sciences$$v23$$x1422-0067$$y2022
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