Journal Article (Review Article)

DZNE-2022-00075

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Propagation and Dissemination Strategies of Transmissible Spongiform Encephalopathy Agents in Mammalian Cells

Heumueller, S.-E. (First author)DZNE* ; Hornberger, A. C.DZNE* ; Hebestreit, A.DZNE* ; Hossinger, A.DZNE* ; Vorberg, I. (Last author)DZNE*

2022
Molecular Diversity Preservation International Basel

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Please use a persistent id in citations: doi:10.3390/ijms23062909

Abstract: Transmissible spongiform encephalopathies or prion disorders are fatal infectious diseases that cause characteristic spongiform degeneration in the central nervous system. The causative agent, the so-called prion, is an unconventional infectious agent that propagates by converting the host-encoded cellular prion protein PrP into ordered protein aggregates with infectious properties. Prions are devoid of coding nucleic acid and thus rely on the host cell machinery for propagation. While it is now established that, in addition to PrP, other cellular factors or processes determine the susceptibility of cell lines to prion infection, exact factors and cellular processes remain broadly obscure. Still, cellular models have uncovered important aspects of prion propagation and revealed intercellular dissemination strategies shared with other intracellular pathogens. Here, we summarize what we learned about the processes of prion invasion, intracellular replication and subsequent dissemination from ex vivo cell models. View Full-Text

Keyword(s): Animals (MeSH) ; Central Nervous System: metabolism (MeSH) ; Mammals: metabolism (MeSH) ; Prion Diseases: metabolism (MeSH) ; Prion Proteins (MeSH) ; Prions: metabolism (MeSH)

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Contributing Institute(s):

1. Prion Cell Biology (AG Vorberg)

Research Program(s):

1. 352 - Disease Mechanisms (POF4-352) (POF4-352)

Appears in the scientific report 2022

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