TY  - JOUR
AU  - Heumueller, Stefanie-Elisabeth
AU  - Hornberger, Annika C.
AU  - Hebestreit, Alina
AU  - Hossinger, André
AU  - Vorberg, Ina
TI  - Propagation and Dissemination Strategies of Transmissible Spongiform Encephalopathy Agents in Mammalian Cells
JO  - International journal of molecular sciences
VL  - 23
IS  - 6
SN  - 1422-0067
CY  - Basel
PB  - Molecular Diversity Preservation International
M1  - DZNE-2022-00075
SP  - 2909
PY  - 2022
AB  - Transmissible spongiform encephalopathies or prion disorders are fatal infectious diseases that cause characteristic spongiform degeneration in the central nervous system. The causative agent, the so-called prion, is an unconventional infectious agent that propagates by converting the host-encoded cellular prion protein PrP into ordered protein aggregates with infectious properties. Prions are devoid of coding nucleic acid and thus rely on the host cell machinery for propagation. While it is now established that, in addition to PrP, other cellular factors or processes determine the susceptibility of cell lines to prion infection, exact factors and cellular processes remain broadly obscure. Still, cellular models have uncovered important aspects of prion propagation and revealed intercellular dissemination strategies shared with other intracellular pathogens. Here, we summarize what we learned about the processes of prion invasion, intracellular replication and subsequent dissemination from ex vivo cell models. View Full-Text
KW  - Animals
KW  - Central Nervous System: metabolism
KW  - Mammals: metabolism
KW  - Prion Diseases: metabolism
KW  - Prion Proteins
KW  - Prions: metabolism
LB  - PUB:(DE-HGF)16
C2  - pmc:PMC8949484
C6  - pmid:35328330
DO  - DOI:10.3390/ijms23062909
UR  - https://pub.dzne.de/record/163295
ER  -