% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Heumueller:163295,
      author       = {Heumueller, Stefanie-Elisabeth and Hornberger, Annika C.
                      and Hebestreit, Alina and Hossinger, André and Vorberg,
                      Ina},
      title        = {{P}ropagation and {D}issemination {S}trategies of
                      {T}ransmissible {S}pongiform {E}ncephalopathy {A}gents in
                      {M}ammalian {C}ells},
      journal      = {International journal of molecular sciences},
      volume       = {23},
      number       = {6},
      issn         = {1422-0067},
      address      = {Basel},
      publisher    = {Molecular Diversity Preservation International},
      reportid     = {DZNE-2022-00075},
      pages        = {2909},
      year         = {2022},
      abstract     = {Transmissible spongiform encephalopathies or prion
                      disorders are fatal infectious diseases that cause
                      characteristic spongiform degeneration in the central
                      nervous system. The causative agent, the so-called prion, is
                      an unconventional infectious agent that propagates by
                      converting the host-encoded cellular prion protein PrP into
                      ordered protein aggregates with infectious properties.
                      Prions are devoid of coding nucleic acid and thus rely on
                      the host cell machinery for propagation. While it is now
                      established that, in addition to PrP, other cellular factors
                      or processes determine the susceptibility of cell lines to
                      prion infection, exact factors and cellular processes remain
                      broadly obscure. Still, cellular models have uncovered
                      important aspects of prion propagation and revealed
                      intercellular dissemination strategies shared with other
                      intracellular pathogens. Here, we summarize what we learned
                      about the processes of prion invasion, intracellular
                      replication and subsequent dissemination from ex vivo cell
                      models. View Full-Text},
      subtyp        = {Review Article},
      keywords     = {Animals / Central Nervous System: metabolism / Mammals:
                      metabolism / Prion Diseases: metabolism / Prion Proteins /
                      Prions: metabolism},
      cin          = {AG Vorberg},
      ddc          = {540},
      cid          = {I:(DE-2719)1013004},
      pnm          = {352 - Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)16},
      pmc          = {pmc:PMC8949484},
      pubmed       = {pmid:35328330},
      doi          = {10.3390/ijms23062909},
      url          = {https://pub.dzne.de/record/163295},
}