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000163442 0247_ $$2doi$$a10.1111/psyg.12802
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000163442 0247_ $$2ISSN$$a1346-3500
000163442 0247_ $$2ISSN$$a1479-8301
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000163442 037__ $$aDZNE-2022-00202
000163442 041__ $$aEnglish
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000163442 1001_ $$aLoessner, Lorenz$$b0
000163442 245__ $$aPredictors of subjective cognitive deficits in patients with mild cognitive impairment.
000163442 260__ $$aOxford [u.a.]$$bWiley-Blackwell$$c2022
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000163442 520__ $$aDetailed examination of cognitive deficits in patients with mild cognitive impairment (MCI) yields substantial diagnostic and prognostic value, specifically with respect to memory. Magnitude and characteristics of subjective cognitive deficits, however, often receive less attention in this population at risk for developing dementia.We investigated predictors of subjective cognitive deficits in patients with MCI, using a detailed assessment for such impairments associated with different cognitive domains, as well as demographic and clinical variables including magnetic resonance imaging data.The strongest predictor for subjective memory deficits was depressed mood, whereas subjective performance issues associated with attention or executive functions also corresponded to measurable impairments in the respective cognitive domains. Reduced hippocampal thickness and hemispheric entorhinal cortex thickness asymmetry were associated with objective memory impairment but not with subjective deficits or symptoms of depression.Whereas low objective memory performance and reduced cortical thickness within medial temporal lobe subregions could be associated with neurodegeneration, greater subjective memory deficits in patients with MCI may indicate psychological burden.
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000163442 650_7 $$2Other$$ahippocampus
000163442 650_7 $$2Other$$amagnetic resonance imaging
000163442 650_7 $$2Other$$amemory
000163442 650_7 $$2Other$$amild cognitive impairment
000163442 650_7 $$2Other$$asubjective cognitive deficits
000163442 650_2 $$2MeSH$$aCognition
000163442 650_2 $$2MeSH$$aCognition Disorders: diagnosis
000163442 650_2 $$2MeSH$$aCognitive Dysfunction: complications
000163442 650_2 $$2MeSH$$aCognitive Dysfunction: pathology
000163442 650_2 $$2MeSH$$aHippocampus: pathology
000163442 650_2 $$2MeSH$$aHumans
000163442 650_2 $$2MeSH$$aMagnetic Resonance Imaging: methods
000163442 650_2 $$2MeSH$$aMemory Disorders: diagnosis
000163442 650_2 $$2MeSH$$aNeuropsychological Tests
000163442 7001_ $$aMatthes, Claudia$$b1
000163442 7001_ $$0P:(DE-2719)9000458$$aHaussmann, Robert$$b2$$udzne
000163442 7001_ $$0P:(DE-2719)2812107$$aBrandt, Moritz D$$b3$$udzne
000163442 7001_ $$aSauer, Cathrin$$b4
000163442 7001_ $$aEspin, Melanie$$b5
000163442 7001_ $$aNoppes, Felix$$b6
000163442 7001_ $$0P:(DE-2719)2812330$$aWerner, Annett$$b7$$udzne
000163442 7001_ $$aLinn, Jennifer$$b8
000163442 7001_ $$aHummel, Thomas$$b9
000163442 7001_ $$aHaehner, Antje$$b10
000163442 7001_ $$0P:(DE-2719)2501739$$aDonix, Markus$$b11$$eLast author$$udzne
000163442 773__ $$0PERI:(DE-600)2110287-9$$a10.1111/psyg.12802$$gVol. 22, no. 2, p. 210 - 217$$n2$$p210 - 217$$tPsychogeriatrics$$v22$$x1479-8301$$y2022
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