Journal Article

DZNE-2022-00202

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Predictors of subjective cognitive deficits in patients with mild cognitive impairment.

Loessner, L. ; Matthes, C. ; Haussmann, R.Extern* ; Brandt, M. D.DZNE* ; Sauer, C. ; Espin, M. ; Noppes, F. ; Werner, A.DZNE* ; Linn, J. ; Hummel, T. ; Haehner, A. ; Donix, M. (Last author)DZNE*

2022
Wiley-Blackwell Oxford [u.a.]

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Please use a persistent id in citations: doi:10.1111/psyg.12802

Abstract: Detailed examination of cognitive deficits in patients with mild cognitive impairment (MCI) yields substantial diagnostic and prognostic value, specifically with respect to memory. Magnitude and characteristics of subjective cognitive deficits, however, often receive less attention in this population at risk for developing dementia.We investigated predictors of subjective cognitive deficits in patients with MCI, using a detailed assessment for such impairments associated with different cognitive domains, as well as demographic and clinical variables including magnetic resonance imaging data.The strongest predictor for subjective memory deficits was depressed mood, whereas subjective performance issues associated with attention or executive functions also corresponded to measurable impairments in the respective cognitive domains. Reduced hippocampal thickness and hemispheric entorhinal cortex thickness asymmetry were associated with objective memory impairment but not with subjective deficits or symptoms of depression.Whereas low objective memory performance and reduced cortical thickness within medial temporal lobe subregions could be associated with neurodegeneration, greater subjective memory deficits in patients with MCI may indicate psychological burden.

Keyword(s): Cognition (MeSH) ; Cognition Disorders: diagnosis (MeSH) ; Cognitive Dysfunction: complications (MeSH) ; Cognitive Dysfunction: pathology (MeSH) ; Hippocampus: pathology (MeSH) ; Humans (MeSH) ; Magnetic Resonance Imaging: methods (MeSH) ; Memory Disorders: diagnosis (MeSH) ; Neuropsychological Tests (MeSH) ; hippocampus ; magnetic resonance imaging ; memory ; mild cognitive impairment ; subjective cognitive deficits

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Contributing Institute(s):

1. Clinical Study Team Dresden (Clinical Study Team Dresden ; AG Falkenburger)
2. Clinical Planning and Intersite Group (AG Donix)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2022

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Database coverage:
; ; ; Clarivate Analytics Master Journal List ; DEAL Wiley ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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