TY  - JOUR
AU  - Loessner, Lorenz
AU  - Matthes, Claudia
AU  - Haussmann, Robert
AU  - Brandt, Moritz D
AU  - Sauer, Cathrin
AU  - Espin, Melanie
AU  - Noppes, Felix
AU  - Werner, Annett
AU  - Linn, Jennifer
AU  - Hummel, Thomas
AU  - Haehner, Antje
AU  - Donix, Markus
TI  - Predictors of subjective cognitive deficits in patients with mild cognitive impairment.
JO  - Psychogeriatrics
VL  - 22
IS  - 2
SN  - 1479-8301
CY  - Oxford [u.a.]
PB  - Wiley-Blackwell
M1  - DZNE-2022-00202
SP  - 210 - 217
PY  - 2022
AB  - Detailed examination of cognitive deficits in patients with mild cognitive impairment (MCI) yields substantial diagnostic and prognostic value, specifically with respect to memory. Magnitude and characteristics of subjective cognitive deficits, however, often receive less attention in this population at risk for developing dementia.We investigated predictors of subjective cognitive deficits in patients with MCI, using a detailed assessment for such impairments associated with different cognitive domains, as well as demographic and clinical variables including magnetic resonance imaging data.The strongest predictor for subjective memory deficits was depressed mood, whereas subjective performance issues associated with attention or executive functions also corresponded to measurable impairments in the respective cognitive domains. Reduced hippocampal thickness and hemispheric entorhinal cortex thickness asymmetry were associated with objective memory impairment but not with subjective deficits or symptoms of depression.Whereas low objective memory performance and reduced cortical thickness within medial temporal lobe subregions could be associated with neurodegeneration, greater subjective memory deficits in patients with MCI may indicate psychological burden.
KW  - Cognition
KW  - Cognition Disorders: diagnosis
KW  - Cognitive Dysfunction: complications
KW  - Cognitive Dysfunction: pathology
KW  - Hippocampus: pathology
KW  - Humans
KW  - Magnetic Resonance Imaging: methods
KW  - Memory Disorders: diagnosis
KW  - Neuropsychological Tests
KW  - hippocampus (Other)
KW  - magnetic resonance imaging (Other)
KW  - memory (Other)
KW  - mild cognitive impairment (Other)
KW  - subjective cognitive deficits (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:34939254
DO  - DOI:10.1111/psyg.12802
UR  - https://pub.dzne.de/record/163442
ER  -