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@ARTICLE{Loessner:163442,
      author       = {Loessner, Lorenz and Matthes, Claudia and Haussmann, Robert
                      and Brandt, Moritz D and Sauer, Cathrin and Espin, Melanie
                      and Noppes, Felix and Werner, Annett and Linn, Jennifer and
                      Hummel, Thomas and Haehner, Antje and Donix, Markus},
      title        = {{P}redictors of subjective cognitive deficits in patients
                      with mild cognitive impairment.},
      journal      = {Psychogeriatrics},
      volume       = {22},
      number       = {2},
      issn         = {1479-8301},
      address      = {Oxford [u.a.]},
      publisher    = {Wiley-Blackwell},
      reportid     = {DZNE-2022-00202},
      pages        = {210 - 217},
      year         = {2022},
      abstract     = {Detailed examination of cognitive deficits in patients with
                      mild cognitive impairment (MCI) yields substantial
                      diagnostic and prognostic value, specifically with respect
                      to memory. Magnitude and characteristics of subjective
                      cognitive deficits, however, often receive less attention in
                      this population at risk for developing dementia.We
                      investigated predictors of subjective cognitive deficits in
                      patients with MCI, using a detailed assessment for such
                      impairments associated with different cognitive domains, as
                      well as demographic and clinical variables including
                      magnetic resonance imaging data.The strongest predictor for
                      subjective memory deficits was depressed mood, whereas
                      subjective performance issues associated with attention or
                      executive functions also corresponded to measurable
                      impairments in the respective cognitive domains. Reduced
                      hippocampal thickness and hemispheric entorhinal cortex
                      thickness asymmetry were associated with objective memory
                      impairment but not with subjective deficits or symptoms of
                      depression.Whereas low objective memory performance and
                      reduced cortical thickness within medial temporal lobe
                      subregions could be associated with neurodegeneration,
                      greater subjective memory deficits in patients with MCI may
                      indicate psychological burden.},
      keywords     = {Cognition / Cognition Disorders: diagnosis / Cognitive
                      Dysfunction: complications / Cognitive Dysfunction:
                      pathology / Hippocampus: pathology / Humans / Magnetic
                      Resonance Imaging: methods / Memory Disorders: diagnosis /
                      Neuropsychological Tests / hippocampus (Other) / magnetic
                      resonance imaging (Other) / memory (Other) / mild cognitive
                      impairment (Other) / subjective cognitive deficits (Other)},
      cin          = {Clinical Study Team Dresden ; AG Falkenburger / AG Donix},
      ddc          = {610},
      cid          = {I:(DE-2719)1710012 / I:(DE-2719)1710008},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34939254},
      doi          = {10.1111/psyg.12802},
      url          = {https://pub.dzne.de/record/163442},
}