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001     163442
005     20230915090520.0
024 7 _ |a 10.1111/psyg.12802
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024 7 _ |a 1346-3500
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024 7 _ |a 1479-8301
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037 _ _ |a DZNE-2022-00202
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Loessner, Lorenz
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245 _ _ |a Predictors of subjective cognitive deficits in patients with mild cognitive impairment.
260 _ _ |a Oxford [u.a.]
|c 2022
|b Wiley-Blackwell
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520 _ _ |a Detailed examination of cognitive deficits in patients with mild cognitive impairment (MCI) yields substantial diagnostic and prognostic value, specifically with respect to memory. Magnitude and characteristics of subjective cognitive deficits, however, often receive less attention in this population at risk for developing dementia.We investigated predictors of subjective cognitive deficits in patients with MCI, using a detailed assessment for such impairments associated with different cognitive domains, as well as demographic and clinical variables including magnetic resonance imaging data.The strongest predictor for subjective memory deficits was depressed mood, whereas subjective performance issues associated with attention or executive functions also corresponded to measurable impairments in the respective cognitive domains. Reduced hippocampal thickness and hemispheric entorhinal cortex thickness asymmetry were associated with objective memory impairment but not with subjective deficits or symptoms of depression.Whereas low objective memory performance and reduced cortical thickness within medial temporal lobe subregions could be associated with neurodegeneration, greater subjective memory deficits in patients with MCI may indicate psychological burden.
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650 _ 7 |a hippocampus
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650 _ 7 |a magnetic resonance imaging
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650 _ 7 |a memory
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650 _ 7 |a mild cognitive impairment
|2 Other
650 _ 7 |a subjective cognitive deficits
|2 Other
650 _ 2 |a Cognition
|2 MeSH
650 _ 2 |a Cognition Disorders: diagnosis
|2 MeSH
650 _ 2 |a Cognitive Dysfunction: complications
|2 MeSH
650 _ 2 |a Cognitive Dysfunction: pathology
|2 MeSH
650 _ 2 |a Hippocampus: pathology
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Magnetic Resonance Imaging: methods
|2 MeSH
650 _ 2 |a Memory Disorders: diagnosis
|2 MeSH
650 _ 2 |a Neuropsychological Tests
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700 1 _ |a Matthes, Claudia
|b 1
700 1 _ |a Haussmann, Robert
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700 1 _ |a Brandt, Moritz D
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700 1 _ |a Sauer, Cathrin
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700 1 _ |a Espin, Melanie
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700 1 _ |a Noppes, Felix
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700 1 _ |a Werner, Annett
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700 1 _ |a Linn, Jennifer
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700 1 _ |a Hummel, Thomas
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700 1 _ |a Haehner, Antje
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700 1 _ |a Donix, Markus
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773 _ _ |a 10.1111/psyg.12802
|g Vol. 22, no. 2, p. 210 - 217
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|t Psychogeriatrics
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856 4 _ |y OpenAccess
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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