TY  - JOUR
AU  - Heisterkamp, Patrick
AU  - Borsch, Oliver
AU  - Lezama, Nundehui Diaz
AU  - Gasparini, Sylvia
AU  - Fathima, Adeeba
AU  - Carvalho, Livia S
AU  - Wagner, Felix
AU  - Karl, Mike O
AU  - Schlierf, Michael
AU  - Ader, Marius
TI  - Evidence for endogenous exchange of cytoplasmic material between a subset of cone and rod photoreceptors within the adult mammalian retina via direct cell-cell connections.
JO  - Experimental eye research
VL  - 219
SN  - 0014-4835
CY  - London
PB  - Academic Press
M1  - DZNE-2022-00452
SP  - 109033
PY  - 2022
N1  - (CC BY-NC-ND)
AB  - Photoreceptor cell transplantation into the mouse retina has been shown to result in the transfer of cytoplasmic material between donor and host photoreceptors. Recently it has been found that this inter-photoreceptor material transfer process is likely to be mediated by nanotube-like structures connecting donor and host photoreceptors. By leveraging cone-specific reporter mice and super-resolution microscopy we provide evidence for the transfer of cytoplasmic material also from endogenous cones to endogenous rod photoreceptors and the existence of nanotube-like cell-cell connections possibly mediating this process in the adult mouse retina, together with preliminary data indicating that horizontal material transfer may also occur in the human retina.
KW  - Animals
KW  - Mammals
KW  - Mice
KW  - Retina
KW  - Retinal Cone Photoreceptor Cells
KW  - Retinal Rod Photoreceptor Cells
KW  - Cell-cell connection (Other)
KW  - Cone (Other)
KW  - Material transfer (Other)
KW  - Photoreceptor (Other)
KW  - Rod (Other)
KW  - STORM (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:35288107
DO  - DOI:10.1016/j.exer.2022.109033
UR  - https://pub.dzne.de/record/163713
ER  -