Journal Article

DZNE-2022-00452

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Evidence for endogenous exchange of cytoplasmic material between a subset of cone and rod photoreceptors within the adult mammalian retina via direct cell-cell connections.

Heisterkamp, P. ; Borsch, O. ; Lezama, N. D. ; Gasparini, S. ; Fathima, A. ; Carvalho, L. S. ; Wagner, F.DZNE* ; Karl, M. O.DZNE* ; Schlierf, M. ; Ader, M.

2022
Academic Press London

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Please use a persistent id in citations: doi:10.1016/j.exer.2022.109033

Abstract: Photoreceptor cell transplantation into the mouse retina has been shown to result in the transfer of cytoplasmic material between donor and host photoreceptors. Recently it has been found that this inter-photoreceptor material transfer process is likely to be mediated by nanotube-like structures connecting donor and host photoreceptors. By leveraging cone-specific reporter mice and super-resolution microscopy we provide evidence for the transfer of cytoplasmic material also from endogenous cones to endogenous rod photoreceptors and the existence of nanotube-like cell-cell connections possibly mediating this process in the adult mouse retina, together with preliminary data indicating that horizontal material transfer may also occur in the human retina.

Keyword(s): Animals (MeSH) ; Mammals (MeSH) ; Mice (MeSH) ; Retina (MeSH) ; Retinal Cone Photoreceptor Cells (MeSH) ; Retinal Rod Photoreceptor Cells (MeSH) ; Cell-cell connection ; Cone ; Material transfer ; Photoreceptor ; Rod ; STORM

Note: (CC BY-NC-ND)

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Contributing Institute(s):

1. Retinal Regeneration and Degeneration (AG Karl)

Research Program(s):

1. 352 - Disease Mechanisms (POF4-352) (POF4-352)

Appears in the scientific report 2022

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Database coverage:
; ; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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