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@ARTICLE{Scuteri:163759,
      author       = {Scuteri, Damiana and Tonin, Paolo and Nicotera, Pierluigi
                      and Bagetta, Giacinto and Corasaniti, Maria Tiziana},
      title        = {{R}eal world considerations for newly approved {CGRP}
                      receptor antagonists in migraine care.},
      journal      = {Expert review of neurotherapeutics},
      volume       = {22},
      number       = {3},
      issn         = {1473-7175},
      address      = {Abingdon},
      publisher    = {Taylor $\&$ Francis Group},
      reportid     = {DZNE-2022-00498},
      pages        = {221 - 230},
      year         = {2022},
      abstract     = {Migraine is the leading cause of years lived with
                      disability in people under 50. Electrophysiological
                      phenomena at the basis of prodromal and headache attack
                      phases and of chronification processes involve
                      calcitonin-gene related peptide (CGRP) as a fundamental
                      player become a game changer of migraine pharmacotherapy.The
                      purpose of the present review is to retrace fundamental
                      stages of CGRP from its discovery to the role in migraine
                      pathogenesis and therapy to underscore the change of
                      paradigm offered by the newly approved small molecules to
                      antagonize CGRP receptor, the gepants. In particular, the
                      development of this new class is gone over from the initial
                      synthesis of C-terminus truncated CGRP antagonists to the
                      development of the first generation of gepants ending with
                      Zavegepant that can be considered the third generation.The
                      history of CGRP in migraine draws the successful road to
                      follow for key signaling pathways of modulation of
                      nociceptive facilitation by diencephalic and brainstem
                      nuclei, including dopaminergic neurotransmission, orexin A
                      and the large-conductance calcium-activated potassium (BKCa)
                      and ATP-sensitive potassium (KATP) channels also
                      investigating the potential of essential oils and the role
                      of polymorphisms. Real-world post marketing long-term data
                      are needed for gepants.},
      subtyp        = {Review Article},
      keywords     = {Calcitonin Gene-Related Peptide / Calcitonin Gene-Related
                      Peptide Receptor Antagonists: pharmacology / Calcitonin
                      Gene-Related Peptide Receptor Antagonists: therapeutic use /
                      Headache: drug therapy / Humans / Migraine Disorders: drug
                      therapy / Migraine Disorders: metabolism / Receptors,
                      Calcitonin Gene-Related Peptide / Atogepant (Other) / CGRP
                      antagonists (Other) / gepants (Other) / migraine (Other) /
                      rimegepant (Other) / ubrogepant (Other) / vazegepant (Other)
                      / Calcitonin Gene-Related Peptide Receptor Antagonists (NLM
                      Chemicals) / Receptors, Calcitonin Gene-Related Peptide (NLM
                      Chemicals) / Calcitonin Gene-Related Peptide (NLM
                      Chemicals)},
      cin          = {AG Bano / Scientific board},
      ddc          = {610},
      cid          = {I:(DE-2719)1013003 / I:(DE-2719)1030000},
      pnm          = {351 - Brain Function (POF4-351)},
      pid          = {G:(DE-HGF)POF4-351},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35240905},
      doi          = {10.1080/14737175.2022.2049758},
      url          = {https://pub.dzne.de/record/163759},
}