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| Home > Publications Database > Real world considerations for newly approved CGRP receptor antagonists in migraine care. |
| Journal Article (Review Article) | DZNE-2022-00498 |
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2022
Taylor & Francis Group
Abingdon
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Please use a persistent id in citations: doi:10.1080/14737175.2022.2049758
Abstract: Migraine is the leading cause of years lived with disability in people under 50. Electrophysiological phenomena at the basis of prodromal and headache attack phases and of chronification processes involve calcitonin-gene related peptide (CGRP) as a fundamental player become a game changer of migraine pharmacotherapy.The purpose of the present review is to retrace fundamental stages of CGRP from its discovery to the role in migraine pathogenesis and therapy to underscore the change of paradigm offered by the newly approved small molecules to antagonize CGRP receptor, the gepants. In particular, the development of this new class is gone over from the initial synthesis of C-terminus truncated CGRP antagonists to the development of the first generation of gepants ending with Zavegepant that can be considered the third generation.The history of CGRP in migraine draws the successful road to follow for key signaling pathways of modulation of nociceptive facilitation by diencephalic and brainstem nuclei, including dopaminergic neurotransmission, orexin A and the large-conductance calcium-activated potassium (BKCa) and ATP-sensitive potassium (KATP) channels also investigating the potential of essential oils and the role of polymorphisms. Real-world post marketing long-term data are needed for gepants.
Keyword(s): Calcitonin Gene-Related Peptide (MeSH) ; Calcitonin Gene-Related Peptide Receptor Antagonists: pharmacology (MeSH) ; Calcitonin Gene-Related Peptide Receptor Antagonists: therapeutic use (MeSH) ; Headache: drug therapy (MeSH) ; Humans (MeSH) ; Migraine Disorders: drug therapy (MeSH) ; Migraine Disorders: metabolism (MeSH) ; Receptors, Calcitonin Gene-Related Peptide (MeSH) ; Atogepant ; CGRP antagonists ; gepants ; migraine ; rimegepant ; ubrogepant ; vazegepant ; Calcitonin Gene-Related Peptide Receptor Antagonists ; Receptors, Calcitonin Gene-Related Peptide ; Calcitonin Gene-Related Peptide
; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Essential Science Indicators ; IF < 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection
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