TY  - JOUR
AU  - Wagemann, Olivia
AU  - Loosli, Sandra V
AU  - Vöglein, Jonathan
AU  - Prix, Catharina
AU  - Wlasich, Elisabeth
AU  - Nuebling, Georg Sebastian Otto
AU  - Danek, Adrian
AU  - Levin, Johannes
TI  - Regression bei jungen Erwachsenen mit einem Down-Syndrom: Eine Fallserie.
JO  - Fortschritte der Neurologie, Psychiatrie
VL  - 90
IS  - 10
SN  - 0015-8194
CY  - Stuttgart [u.a.]
PB  - Thieme
M1  - DZNE-2022-00625
SP  - 465-470
PY  - 2022
AB  - Regression in young adults with Down syndrome can present itself with an acute loss of acquired skills and change in behavior. The aim of our case series was to describe the heterogeneous clinical presentation of this syndrome as well as accompanying diagnostic and therapeutic challenges and consequences.All three patients were assessed with the CAMDEX-DS (Cambridge Examination for Mental Disorders of Older People with Down Syndrome and Others with Intellectual Disabilities) and the criteria published by the DSMIG-USA (Down-Syndrome Medical Interest Group USA).After ruling out somatic or other psychiatric causes, the application of the DSMIG-USA criteria resulted in diagnosing at least a probable unexplained regression in all three patients.The thorough diagnostic investigation of unexplained acute regression in young adults with Down syndrome allows for quick initiation of therapeutic and supportive measures. Using the DMSIG-USA criteria facilitates the assessment of the underlying diffuse and heterogenous pathology.
KW  - Aged
KW  - Cognition
KW  - Down Syndrome: complications
KW  - Humans
KW  - Intellectual Disability: complications
KW  - Young Adult
LB  - PUB:(DE-HGF)16
C6  - pmid:35405744
DO  - DOI:10.1055/a-1743-2915
UR  - https://pub.dzne.de/record/163951
ER  -