TY  - JOUR
AU  - Cable, Jennifer
AU  - Weber-Ban, Eilika
AU  - Clausen, Tim
AU  - Walters, Kylie J
AU  - Sharon, Michal
AU  - Finley, Daniel J
AU  - Gu, Yangnan
AU  - Hanna, John
AU  - Feng, Yue
AU  - Martens, Sascha
AU  - Simonsen, Anne
AU  - Hansen, Malene
AU  - Zhang, Hong
AU  - Goodwin, Jonathan M
AU  - Reggio, Alessio
AU  - Chang, Chunmei
AU  - Ge, Liang
AU  - Schulman, Brenda A
AU  - Deshaies, Raymond J
AU  - Dikic, Ivan
AU  - Harper, J Wade
AU  - Wertz, Ingrid E
AU  - Thomä, Nicolas H
AU  - Słabicki, Mikołaj
AU  - Frydman, Judith
AU  - Jakob, Ursula
AU  - David, Della C
AU  - Bennett, Eric J
AU  - Bertozzi, Carolyn R
AU  - Sardana, Richa
AU  - Eapen, Vinay V
AU  - Carra, Serena
TI  - Targeted protein degradation: from small molecules to complex organelles-a Keystone Symposia report.
JO  - Annals of the New York Academy of Sciences
VL  - 1510
IS  - 1
SN  - 0077-8923
CY  - New York, NY
PB  - New York Acad. of Sciences
M1  - DZNE-2022-00632
SP  - 79 - 99
PY  - 2022
AB  - Targeted protein degradation is critical for proper cellular function and development. Protein degradation pathways, such as the ubiquitin proteasomes system, autophagy, and endosome-lysosome pathway, must be tightly regulated to ensure proper elimination of misfolded and aggregated proteins and regulate changing protein levels during cellular differentiation, while ensuring that normal proteins remain unscathed. Protein degradation pathways have also garnered interest as a means to selectively eliminate target proteins that may be difficult to inhibit via other mechanisms. On June 7 and 8, 2021, several experts in protein degradation pathways met virtually for the Keystone eSymposium 'Targeting protein degradation: from small molecules to complex organelles.' The event brought together researchers working in different protein degradation pathways in an effort to begin to develop a holistic, integrated vision of protein degradation that incorporates all the major pathways to understand how changes in them can lead to disease pathology and, alternatively, how they can be leveraged for novel therapeutics.
KW  - Autophagy: physiology
KW  - Humans
KW  - Organelles
KW  - Proteasome Endopeptidase Complex: metabolism
KW  - Proteins: metabolism
KW  - Proteolysis
KW  - Ubiquitin: metabolism
KW  - aggregation (Other)
KW  - autophagy (Other)
KW  - lysophagy (Other)
KW  - proteasome (Other)
KW  - protein degradation (Other)
KW  - ubiquitin (Other)
KW  - Proteins (NLM Chemicals)
KW  - Ubiquitin (NLM Chemicals)
KW  - Proteasome Endopeptidase Complex (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:35000205
DO  - DOI:10.1111/nyas.14745
UR  - https://pub.dzne.de/record/163963
ER  -