Journal Article

DZNE-2022-00632

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Targeted protein degradation: from small molecules to complex organelles-a Keystone Symposia report.

Cable, J. ; Weber-Ban, E. ; Clausen, T. ; Walters, K. J. ; Sharon, M. ; Finley, D. J. ; Gu, Y. ; Hanna, J. ; Feng, Y. ; Martens, S. ; Simonsen, A. ; Hansen, M. ; Zhang, H. ; Goodwin, J. M. ; Reggio, A. ; Chang, C. ; Ge, L. ; Schulman, B. A. ; Deshaies, R. J. ; Dikic, I. ; Harper, J. W. ; Wertz, I. E. ; Thomä, N. H. ; Słabicki, M. ; Frydman, J. ; Jakob, U. ; David, D. C.DZNE* ; Bennett, E. J. ; Bertozzi, C. R. ; Sardana, R. ; Eapen, V. V. ; Carra, S.

2022
New York Acad. of Sciences New York, NY

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Please use a persistent id in citations: doi:10.1111/nyas.14745

Abstract: Targeted protein degradation is critical for proper cellular function and development. Protein degradation pathways, such as the ubiquitin proteasomes system, autophagy, and endosome-lysosome pathway, must be tightly regulated to ensure proper elimination of misfolded and aggregated proteins and regulate changing protein levels during cellular differentiation, while ensuring that normal proteins remain unscathed. Protein degradation pathways have also garnered interest as a means to selectively eliminate target proteins that may be difficult to inhibit via other mechanisms. On June 7 and 8, 2021, several experts in protein degradation pathways met virtually for the Keystone eSymposium 'Targeting protein degradation: from small molecules to complex organelles.' The event brought together researchers working in different protein degradation pathways in an effort to begin to develop a holistic, integrated vision of protein degradation that incorporates all the major pathways to understand how changes in them can lead to disease pathology and, alternatively, how they can be leveraged for novel therapeutics.

Keyword(s): Autophagy: physiology (MeSH) ; Humans (MeSH) ; Organelles (MeSH) ; Proteasome Endopeptidase Complex: metabolism (MeSH) ; Proteins: metabolism (MeSH) ; Proteolysis (MeSH) ; Ubiquitin: metabolism (MeSH) ; aggregation ; autophagy ; lysophagy ; proteasome ; protein degradation ; ubiquitin ; Proteins ; Ubiquitin ; Proteasome Endopeptidase Complex

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Contributing Institute(s):

1. Protein Aggregation and Aging (AG David)

Research Program(s):

1. 352 - Disease Mechanisms (POF4-352) (POF4-352)

Appears in the scientific report 2022

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; DEAL Wiley ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection ; Zoological Record

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