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@ARTICLE{Cable:163963,
      author       = {Cable, Jennifer and Weber-Ban, Eilika and Clausen, Tim and
                      Walters, Kylie J and Sharon, Michal and Finley, Daniel J and
                      Gu, Yangnan and Hanna, John and Feng, Yue and Martens,
                      Sascha and Simonsen, Anne and Hansen, Malene and Zhang, Hong
                      and Goodwin, Jonathan M and Reggio, Alessio and Chang,
                      Chunmei and Ge, Liang and Schulman, Brenda A and Deshaies,
                      Raymond J and Dikic, Ivan and Harper, J Wade and Wertz,
                      Ingrid E and Thomä, Nicolas H and Słabicki, Mikołaj and
                      Frydman, Judith and Jakob, Ursula and David, Della C and
                      Bennett, Eric J and Bertozzi, Carolyn R and Sardana, Richa
                      and Eapen, Vinay V and Carra, Serena},
      title        = {{T}argeted protein degradation: from small molecules to
                      complex organelles-a {K}eystone {S}ymposia report.},
      journal      = {Annals of the New York Academy of Sciences},
      volume       = {1510},
      number       = {1},
      issn         = {0077-8923},
      address      = {New York, NY},
      publisher    = {New York Acad. of Sciences},
      reportid     = {DZNE-2022-00632},
      pages        = {79 - 99},
      year         = {2022},
      abstract     = {Targeted protein degradation is critical for proper
                      cellular function and development. Protein degradation
                      pathways, such as the ubiquitin proteasomes system,
                      autophagy, and endosome-lysosome pathway, must be tightly
                      regulated to ensure proper elimination of misfolded and
                      aggregated proteins and regulate changing protein levels
                      during cellular differentiation, while ensuring that normal
                      proteins remain unscathed. Protein degradation pathways have
                      also garnered interest as a means to selectively eliminate
                      target proteins that may be difficult to inhibit via other
                      mechanisms. On June 7 and 8, 2021, several experts in
                      protein degradation pathways met virtually for the Keystone
                      eSymposium 'Targeting protein degradation: from small
                      molecules to complex organelles.' The event brought together
                      researchers working in different protein degradation
                      pathways in an effort to begin to develop a holistic,
                      integrated vision of protein degradation that incorporates
                      all the major pathways to understand how changes in them can
                      lead to disease pathology and, alternatively, how they can
                      be leveraged for novel therapeutics.},
      keywords     = {Autophagy: physiology / Humans / Organelles / Proteasome
                      Endopeptidase Complex: metabolism / Proteins: metabolism /
                      Proteolysis / Ubiquitin: metabolism / aggregation (Other) /
                      autophagy (Other) / lysophagy (Other) / proteasome (Other) /
                      protein degradation (Other) / ubiquitin (Other) / Proteins
                      (NLM Chemicals) / Ubiquitin (NLM Chemicals) / Proteasome
                      Endopeptidase Complex (NLM Chemicals)},
      cin          = {AG David},
      ddc          = {500},
      cid          = {I:(DE-2719)1210004},
      pnm          = {352 - Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35000205},
      doi          = {10.1111/nyas.14745},
      url          = {https://pub.dzne.de/record/163963},
}