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000164055 037__ $$aDZNE-2022-00718
000164055 041__ $$aEnglish
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000164055 1001_ $$0P:(DE-HGF)0$$aLi, Qing$$b0
000164055 245__ $$aImmune response in COVID-19: what is next?
000164055 260__ $$aLondon$$bMacmillan$$c2022
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000164055 520__ $$aThe coronavirus disease 2019 (COVID-19) has been a global pandemic for more than 2 years and it still impacts our daily lifestyle and quality in unprecedented ways. A better understanding of immunity and its regulation in response to SARS-CoV-2 infection is urgently needed. Based on the current literature, we review here the various virus mutations and the evolving disease manifestations along with the alterations of immune responses with specific focuses on the innate immune response, neutrophil extracellular traps, humoral immunity, and cellular immunity. Different types of vaccines were compared and analyzed based on their unique properties to elicit specific immunity. Various therapeutic strategies such as antibody, anti-viral medications and inflammation control were discussed. We predict that with the available and continuously emerging new technologies, more powerful vaccines and administration schedules, more effective medications and better public health measures, the COVID-19 pandemic will be under control in the near future.
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000164055 650_2 $$2MeSH$$aCOVID-19
000164055 650_2 $$2MeSH$$aCOVID-19 Vaccines
000164055 650_2 $$2MeSH$$aHumans
000164055 650_2 $$2MeSH$$aImmunity, Innate
000164055 650_2 $$2MeSH$$aPandemics: prevention & control
000164055 650_2 $$2MeSH$$aSARS-CoV-2
000164055 7001_ $$00000-0002-2571-9367$$aWang, Ying$$b1
000164055 7001_ $$aSun, Qiang$$b2
000164055 7001_ $$00000-0003-2922-9370$$aKnopf, Jasmin$$b3
000164055 7001_ $$00000-0002-0258-2484$$aHerrmann, Martin$$b4
000164055 7001_ $$00000-0003-4312-8955$$aLin, Liangyu$$b5
000164055 7001_ $$00000-0002-3128-9762$$aJiang, Jingting$$b6
000164055 7001_ $$00000-0003-2618-9342$$aShao, Changshun$$b7
000164055 7001_ $$00000-0002-6881-396X$$aLi, Peishan$$b8
000164055 7001_ $$aHe, Xiaozhou$$b9
000164055 7001_ $$aHua, Fei$$b10
000164055 7001_ $$aNiu, Zubiao$$b11
000164055 7001_ $$aMa, Chaobing$$b12
000164055 7001_ $$aZhu, Yichao$$b13
000164055 7001_ $$aIppolito, Giuseppe$$b14
000164055 7001_ $$aPiacentini, Mauro$$b15
000164055 7001_ $$00000-0002-9432-8044$$aEstaquier, Jerome$$b16
000164055 7001_ $$aMelino, Sonia$$b17
000164055 7001_ $$00000-0003-0228-5081$$aWeiss, Felix Daniel$$b18
000164055 7001_ $$00000-0003-0088-5788$$aAndreano, Emanuele$$b19
000164055 7001_ $$0P:(DE-2719)2000062$$aLatz, Eicke$$b20
000164055 7001_ $$0P:(DE-2719)2811660$$aSchultze, Joachim$$b21
000164055 7001_ $$aRappuoli, Rino$$b22
000164055 7001_ $$00000-0001-5578-236X$$aMantovani, Alberto$$b23
000164055 7001_ $$aMak, Tak Wah$$b24
000164055 7001_ $$0P:(DE-2719)9001390$$aMelino, Gerry$$b25
000164055 7001_ $$00000-0001-8964-319X$$aShi, Yufang$$b26
000164055 773__ $$0PERI:(DE-600)1496681-5$$a10.1038/s41418-022-01015-x$$p1107-1122$$tCell death and differentiation$$v29$$x1350-9047$$y2022
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