Journal Article (Review Article)

DZNE-2022-00718

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Immune response in COVID-19: what is next?

Li, Q. ; Wang, Y. ; Sun, Q. ; Knopf, J. ; Herrmann, M. ; Lin, L. ; Jiang, J. ; Shao, C. ; Li, P. ; He, X. ; Hua, F. ; Niu, Z. ; Ma, C. ; Zhu, Y. ; Ippolito, G. ; Piacentini, M. ; Estaquier, J. ; Melino, S. ; Weiss, F. D. ; Andreano, E. ; Latz, E.DZNE* ; Schultze, J.DZNE* ; Rappuoli, R. ; Mantovani, A. ; Mak, T. W. ; Melino, G.DZNE* ; Shi, Y.

2022
Macmillan London

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Please use a persistent id in citations: doi:10.1038/s41418-022-01015-x

Abstract: The coronavirus disease 2019 (COVID-19) has been a global pandemic for more than 2 years and it still impacts our daily lifestyle and quality in unprecedented ways. A better understanding of immunity and its regulation in response to SARS-CoV-2 infection is urgently needed. Based on the current literature, we review here the various virus mutations and the evolving disease manifestations along with the alterations of immune responses with specific focuses on the innate immune response, neutrophil extracellular traps, humoral immunity, and cellular immunity. Different types of vaccines were compared and analyzed based on their unique properties to elicit specific immunity. Various therapeutic strategies such as antibody, anti-viral medications and inflammation control were discussed. We predict that with the available and continuously emerging new technologies, more powerful vaccines and administration schedules, more effective medications and better public health measures, the COVID-19 pandemic will be under control in the near future.

Keyword(s): COVID-19 (MeSH) ; COVID-19 Vaccines (MeSH) ; Humans (MeSH) ; Immunity, Innate (MeSH) ; Pandemics: prevention & control (MeSH) ; SARS-CoV-2 (MeSH)

Note: (CC BY)

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Contributing Institute(s):

1. Innate Immunity in Neurodegeneration (AG Latz)
2. Synaptic Connectivity and Neurodegeneration (AG Nicotera)
3. Clinical Single Cell Omics (CSCO) / Systems Medicine (AG Schultze)

Research Program(s):

1. 351 - Brain Function (POF4-351) (POF4-351)
2. 354 - Disease Prevention and Healthy Aging (POF4-354) (POF4-354)

Appears in the scientific report 2022

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Database coverage:
; ; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 10 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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