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@ARTICLE{Li:164055,
      author       = {Li, Qing and Wang, Ying and Sun, Qiang and Knopf, Jasmin
                      and Herrmann, Martin and Lin, Liangyu and Jiang, Jingting
                      and Shao, Changshun and Li, Peishan and He, Xiaozhou and
                      Hua, Fei and Niu, Zubiao and Ma, Chaobing and Zhu, Yichao
                      and Ippolito, Giuseppe and Piacentini, Mauro and Estaquier,
                      Jerome and Melino, Sonia and Weiss, Felix Daniel and
                      Andreano, Emanuele and Latz, Eicke and Schultze, Joachim and
                      Rappuoli, Rino and Mantovani, Alberto and Mak, Tak Wah and
                      Melino, Gerry and Shi, Yufang},
      title        = {{I}mmune response in {COVID}-19: what is next?},
      journal      = {Cell death and differentiation},
      volume       = {29},
      issn         = {1350-9047},
      address      = {London},
      publisher    = {Macmillan},
      reportid     = {DZNE-2022-00718},
      pages        = {1107-1122},
      year         = {2022},
      note         = {(CC BY)},
      abstract     = {The coronavirus disease 2019 (COVID-19) has been a global
                      pandemic for more than 2 years and it still impacts our
                      daily lifestyle and quality in unprecedented ways. A better
                      understanding of immunity and its regulation in response to
                      SARS-CoV-2 infection is urgently needed. Based on the
                      current literature, we review here the various virus
                      mutations and the evolving disease manifestations along with
                      the alterations of immune responses with specific focuses on
                      the innate immune response, neutrophil extracellular traps,
                      humoral immunity, and cellular immunity. Different types of
                      vaccines were compared and analyzed based on their unique
                      properties to elicit specific immunity. Various therapeutic
                      strategies such as antibody, anti-viral medications and
                      inflammation control were discussed. We predict that with
                      the available and continuously emerging new technologies,
                      more powerful vaccines and administration schedules, more
                      effective medications and better public health measures, the
                      COVID-19 pandemic will be under control in the near future.},
      subtyp        = {Review Article},
      keywords     = {COVID-19 / COVID-19 Vaccines / Humans / Immunity, Innate /
                      Pandemics: prevention $\&$ control / SARS-CoV-2},
      cin          = {AG Latz / AG Nicotera / AG Schultze},
      ddc          = {610},
      cid          = {I:(DE-2719)1013024 / I:(DE-2719)5000018 /
                      I:(DE-2719)1013038},
      pnm          = {351 - Brain Function (POF4-351) / 354 - Disease Prevention
                      and Healthy Aging (POF4-354)},
      pid          = {G:(DE-HGF)POF4-351 / G:(DE-HGF)POF4-354},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35581387},
      pmc          = {pmc:PMC9110941},
      doi          = {10.1038/s41418-022-01015-x},
      url          = {https://pub.dzne.de/record/164055},
}