000164086 001__ 164086
000164086 005__ 20230915090548.0
000164086 0247_ $$2doi$$a10.1093/infdis/jiac103
000164086 0247_ $$2pmid$$apmid:35313340
000164086 0247_ $$2ISSN$$a0022-1899
000164086 0247_ $$2ISSN$$a1537-6613
000164086 0247_ $$2altmetric$$aaltmetric:125146599
000164086 037__ $$aDZNE-2022-00749
000164086 041__ $$aEnglish
000164086 082__ $$a610
000164086 1001_ $$00000-0002-1625-9741$$aToVinh, Michael$$b0
000164086 245__ $$aMitochondrial dysfunction contributes to impaired cytokine production of CD56 bright NK cells from HIV(+) individuals under effective antiviral therapy.
000164086 260__ $$aOxford [u.a.]$$bOxford Univ. Press$$c2022
000164086 3367_ $$2DRIVER$$aarticle
000164086 3367_ $$2DataCite$$aOutput Types/Journal article
000164086 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1665148524_1935
000164086 3367_ $$2BibTeX$$aARTICLE
000164086 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000164086 3367_ $$00$$2EndNote$$aJournal Article
000164086 520__ $$aHIV infection is associated with impaired NK cell activity, which is only incompletely restored under antiretroviral therapy. Analysing the bioenergetics profiles of oxygen consumption, we observed several parameters were significantly reduced in HIV(+) NK cells, indicating a mitochondrial defect. Accordingly, we found HIV(+) CD56 bright NK cells to display a decreased mitochondrial membrane potential and mitochondrial mass. Both parameters were positively correlated with IFNγ production of NK cells. Finally, we demonstrated that stimulation of HIV(+) NK cells with MitoTEMPO, mitochondria-targeting antioxidant, significantly improved IFNγ production. In conclusion, we identified mitochondrial dysfunction as a mechanism that contributes to impaired NK cell function.
000164086 536__ $$0G:(DE-HGF)POF4-899$$a899 - ohne Topic (POF4-899)$$cPOF4-899$$fPOF IV$$x0
000164086 588__ $$aDataset connected to CrossRef, PubMed, , Journals: pub.dzne.de
000164086 650_7 $$2Other$$aHIV
000164086 650_7 $$2Other$$aIFNγ
000164086 650_7 $$2Other$$aNK cell
000164086 650_7 $$2Other$$aimmunometabolism
000164086 650_7 $$2Other$$amitochondrial dysfunction
000164086 693__ $$0EXP:(DE-2719)IDAF-20190308$$5EXP:(DE-2719)IDAF-20190308$$eImage and Data Analysis Facility (CRFS-IDAF) / Bonn$$x0
000164086 7001_ $$aHörr, Gregor$$b1
000164086 7001_ $$aDobrikova, Kristiyana$$b2
000164086 7001_ $$aGotter, Christina$$b3
000164086 7001_ $$aRommel, Clemens$$b4
000164086 7001_ $$aHoffmeister, Christoph$$b5
000164086 7001_ $$aRaabe, Jan$$b6
000164086 7001_ $$aKaiser, Kim M$$b7
000164086 7001_ $$aFinnemann, Claudia$$b8
000164086 7001_ $$00000-0002-7700-2915$$aBischoff, Jenny$$b9
000164086 7001_ $$aRieke, Gereon J$$b10
000164086 7001_ $$aWilhelm, Christoph$$b11
000164086 7001_ $$aSchmitt, Vanessa$$b12
000164086 7001_ $$0P:(DE-2719)2810422$$aMöhl, Christoph$$b13$$udzne
000164086 7001_ $$0P:(DE-2719)2814300$$aAghabeig, Mansoureh$$b14$$udzne
000164086 7001_ $$aSchwarze-Zander, Carolynne$$b15
000164086 7001_ $$aBoesecke, Christoph$$b16
000164086 7001_ $$avan Bremen, Kathrin$$b17
000164086 7001_ $$aWasmuth, Jan-Christian$$b18
000164086 7001_ $$aStrassburg, Christian P$$b19
000164086 7001_ $$aRockstroh, Jürgen K$$b20
000164086 7001_ $$aSpengler, Ulrich$$b21
000164086 7001_ $$aKrämer, Benjamin$$b22
000164086 7001_ $$aNattermann, Jacob$$b23
000164086 773__ $$0PERI:(DE-600)1473843-0$$a10.1093/infdis/jiac103$$gp. jiac103$$n5$$p901-906$$tThe journal of infectious diseases$$v226$$x0022-1899$$y2022
000164086 909CO $$ooai:pub.dzne.de:164086$$pVDB
000164086 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2810422$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b13$$kDZNE
000164086 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2814300$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b14$$kDZNE
000164086 9131_ $$0G:(DE-HGF)POF4-899$$1G:(DE-HGF)POF4-890$$2G:(DE-HGF)POF4-800$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bProgrammungebundene Forschung$$lohne Programm$$vohne Topic$$x0
000164086 9141_ $$y2022
000164086 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2021-02-03
000164086 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2021-02-03
000164086 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2021-02-03
000164086 915__ $$0StatID:(DE-HGF)0430$$2StatID$$aNational-Konsortium$$d2022-11-25$$wger
000164086 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bJ INFECT DIS : 2021$$d2022-11-25
000164086 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2022-11-25
000164086 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2022-11-25
000164086 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2022-11-25
000164086 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2022-11-25
000164086 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2022-11-25
000164086 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2022-11-25
000164086 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2022-11-25
000164086 915__ $$0StatID:(DE-HGF)1110$$2StatID$$aDBCoverage$$bCurrent Contents - Clinical Medicine$$d2022-11-25
000164086 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2022-11-25
000164086 915__ $$0StatID:(DE-HGF)9905$$2StatID$$aIF >= 5$$bJ INFECT DIS : 2021$$d2022-11-25
000164086 9201_ $$0I:(DE-2719)1040200$$kIDAF$$lImage and Data Analysis (IDAF)$$x0
000164086 980__ $$ajournal
000164086 980__ $$aVDB
000164086 980__ $$aI:(DE-2719)1040200
000164086 980__ $$aUNRESTRICTED