Journal Article

DZNE-2022-00749

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Mitochondrial dysfunction contributes to impaired cytokine production of CD56 bright NK cells from HIV(+) individuals under effective antiviral therapy.

ToVinh, M. ; Hörr, G. ; Dobrikova, K. ; Gotter, C. ; Rommel, C. ; Hoffmeister, C. ; Raabe, J. ; Kaiser, K. M. ; Finnemann, C. ; Bischoff, J. ; Rieke, G. J. ; Wilhelm, C. ; Schmitt, V. ; Möhl, C.DZNE* ; Aghabeig, M.DZNE* ; Schwarze-Zander, C. ; Boesecke, C. ; van Bremen, K. ; Wasmuth, J.-C. ; Strassburg, C. P. ; Rockstroh, J. K. ; Spengler, U. ; Krämer, B. ; Nattermann, J.

2022
Oxford Univ. Press Oxford [u.a.]

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Please use a persistent id in citations: doi:10.1093/infdis/jiac103

Abstract: HIV infection is associated with impaired NK cell activity, which is only incompletely restored under antiretroviral therapy. Analysing the bioenergetics profiles of oxygen consumption, we observed several parameters were significantly reduced in HIV(+) NK cells, indicating a mitochondrial defect. Accordingly, we found HIV(+) CD56 bright NK cells to display a decreased mitochondrial membrane potential and mitochondrial mass. Both parameters were positively correlated with IFNγ production of NK cells. Finally, we demonstrated that stimulation of HIV(+) NK cells with MitoTEMPO, mitochondria-targeting antioxidant, significantly improved IFNγ production. In conclusion, we identified mitochondrial dysfunction as a mechanism that contributes to impaired NK cell function.

Keyword(s): HIV ; IFNγ ; NK cell ; immunometabolism ; mitochondrial dysfunction

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Contributing Institute(s):

1. Image and Data Analysis (IDAF) (IDAF)

Research Program(s):

1. 899 - ohne Topic (POF4-899) (POF4-899)

Experiment(s):

1. Image and Data Analysis Facility (CRFS-IDAF) / Bonn

Appears in the scientific report 2022

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; National-Konsortium ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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