TY  - JOUR
AU  - ToVinh, Michael
AU  - Hörr, Gregor
AU  - Dobrikova, Kristiyana
AU  - Gotter, Christina
AU  - Rommel, Clemens
AU  - Hoffmeister, Christoph
AU  - Raabe, Jan
AU  - Kaiser, Kim M
AU  - Finnemann, Claudia
AU  - Bischoff, Jenny
AU  - Rieke, Gereon J
AU  - Wilhelm, Christoph
AU  - Schmitt, Vanessa
AU  - Möhl, Christoph
AU  - Aghabeig, Mansoureh
AU  - Schwarze-Zander, Carolynne
AU  - Boesecke, Christoph
AU  - van Bremen, Kathrin
AU  - Wasmuth, Jan-Christian
AU  - Strassburg, Christian P
AU  - Rockstroh, Jürgen K
AU  - Spengler, Ulrich
AU  - Krämer, Benjamin
AU  - Nattermann, Jacob
TI  - Mitochondrial dysfunction contributes to impaired cytokine production of CD56 bright NK cells from HIV(+) individuals under effective antiviral therapy.
JO  - The journal of infectious diseases
VL  - 226
IS  - 5
SN  - 0022-1899
CY  - Oxford [u.a.]
PB  - Oxford Univ. Press
M1  - DZNE-2022-00749
SP  - 901-906
PY  - 2022
AB  - HIV infection is associated with impaired NK cell activity, which is only incompletely restored under antiretroviral therapy. Analysing the bioenergetics profiles of oxygen consumption, we observed several parameters were significantly reduced in HIV(+) NK cells, indicating a mitochondrial defect. Accordingly, we found HIV(+) CD56 bright NK cells to display a decreased mitochondrial membrane potential and mitochondrial mass. Both parameters were positively correlated with IFNγ production of NK cells. Finally, we demonstrated that stimulation of HIV(+) NK cells with MitoTEMPO, mitochondria-targeting antioxidant, significantly improved IFNγ production. In conclusion, we identified mitochondrial dysfunction as a mechanism that contributes to impaired NK cell function.
KW  - HIV (Other)
KW  - IFNγ (Other)
KW  - NK cell (Other)
KW  - immunometabolism (Other)
KW  - mitochondrial dysfunction (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:35313340
DO  - DOI:10.1093/infdis/jiac103
UR  - https://pub.dzne.de/record/164086
ER  -