Home > Publications Database > Mitochondrial dysfunction contributes to impaired cytokine production of CD56 bright NK cells from HIV(+) individuals under effective antiviral therapy. > print

001     164086
005     20230915090548.0
024 7 _ |a 10.1093/infdis/jiac103
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041 _ _ |a English
082 _ _ |a 610
100 1 _ |a ToVinh, Michael
|0 0000-0002-1625-9741
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245 _ _ |a Mitochondrial dysfunction contributes to impaired cytokine production of CD56 bright NK cells from HIV(+) individuals under effective antiviral therapy.
260 _ _ |a Oxford [u.a.]
|c 2022
|b Oxford Univ. Press
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520 _ _ |a HIV infection is associated with impaired NK cell activity, which is only incompletely restored under antiretroviral therapy. Analysing the bioenergetics profiles of oxygen consumption, we observed several parameters were significantly reduced in HIV(+) NK cells, indicating a mitochondrial defect. Accordingly, we found HIV(+) CD56 bright NK cells to display a decreased mitochondrial membrane potential and mitochondrial mass. Both parameters were positively correlated with IFNγ production of NK cells. Finally, we demonstrated that stimulation of HIV(+) NK cells with MitoTEMPO, mitochondria-targeting antioxidant, significantly improved IFNγ production. In conclusion, we identified mitochondrial dysfunction as a mechanism that contributes to impaired NK cell function.
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650 _ 7 |a HIV
|2 Other
650 _ 7 |a IFNγ
|2 Other
650 _ 7 |a NK cell
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650 _ 7 |a immunometabolism
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650 _ 7 |a mitochondrial dysfunction
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700 1 _ |a Hörr, Gregor
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700 1 _ |a Dobrikova, Kristiyana
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700 1 _ |a Gotter, Christina
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700 1 _ |a Rommel, Clemens
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700 1 _ |a Hoffmeister, Christoph
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700 1 _ |a Raabe, Jan
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700 1 _ |a Kaiser, Kim M
|b 7
700 1 _ |a Finnemann, Claudia
|b 8
700 1 _ |a Bischoff, Jenny
|0 0000-0002-7700-2915
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700 1 _ |a Rieke, Gereon J
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700 1 _ |a Wilhelm, Christoph
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700 1 _ |a Schmitt, Vanessa
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700 1 _ |a Möhl, Christoph
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700 1 _ |a Aghabeig, Mansoureh
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700 1 _ |a Schwarze-Zander, Carolynne
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700 1 _ |a Boesecke, Christoph
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700 1 _ |a van Bremen, Kathrin
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700 1 _ |a Wasmuth, Jan-Christian
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700 1 _ |a Strassburg, Christian P
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700 1 _ |a Rockstroh, Jürgen K
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700 1 _ |a Spengler, Ulrich
|b 21
700 1 _ |a Krämer, Benjamin
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700 1 _ |a Nattermann, Jacob
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773 _ _ |a 10.1093/infdis/jiac103
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|t The journal of infectious diseases
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