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000164200 037__ $$aDZNE-2022-00856
000164200 041__ $$aEnglish
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000164200 1001_ $$0P:(DE-2719)9000347$$aWieghofer, Peter$$b0$$udzne
000164200 245__ $$aMapping the origin and fate of myeloid cells in distinct compartments of the eye by single-cell profiling.
000164200 260__ $$aHoboken, NJ [u.a.]$$bWiley$$c2021
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000164200 520__ $$aSimilar to the brain, the eye is considered an immune-privileged organ where tissue-resident macrophages provide the major immune cell constituents. However, little is known about spatially restricted macrophage subsets within different eye compartments with regard to their origin, function, and fate during health and disease. Here, we combined single-cell analysis, fate mapping, parabiosis, and computational modeling to comprehensively examine myeloid subsets in distinct parts of the eye during homeostasis. This approach allowed us to identify myeloid subsets displaying diverse transcriptional states. During choroidal neovascularization, a typical hallmark of neovascular age-related macular degeneration (AMD), we recognized disease-specific macrophage subpopulations with distinct molecular signatures. Our results highlight the heterogeneity of myeloid subsets and their dynamics in the eye that provide new insights into the innate immune system in this organ which may offer new therapeutic targets for ophthalmological diseases.
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000164200 650_7 $$2Other$$acornea
000164200 650_7 $$2Other$$amacrophages
000164200 650_7 $$2Other$$amicroglia
000164200 650_7 $$2Other$$aretina
000164200 650_7 $$2Other$$asingle-cell RNA-seq
000164200 650_2 $$2MeSH$$aAnimals
000164200 650_2 $$2MeSH$$aChoroid: blood supply
000164200 650_2 $$2MeSH$$aChoroid: embryology
000164200 650_2 $$2MeSH$$aComputational Biology
000164200 650_2 $$2MeSH$$aComputer Simulation
000164200 650_2 $$2MeSH$$aEye: cytology
000164200 650_2 $$2MeSH$$aEye: immunology
000164200 650_2 $$2MeSH$$aEye: metabolism
000164200 650_2 $$2MeSH$$aFemale
000164200 650_2 $$2MeSH$$aHomeostasis: immunology
000164200 650_2 $$2MeSH$$aHumans
000164200 650_2 $$2MeSH$$aImmunity, Innate: immunology
000164200 650_2 $$2MeSH$$aMacrophages: immunology
000164200 650_2 $$2MeSH$$aMacular Degeneration: pathology
000164200 650_2 $$2MeSH$$aMale
000164200 650_2 $$2MeSH$$aMice
000164200 650_2 $$2MeSH$$aMice, Inbred C57BL
000164200 650_2 $$2MeSH$$aMice, Transgenic
000164200 650_2 $$2MeSH$$aMicroglia: physiology
000164200 650_2 $$2MeSH$$aMyeloid Cells: immunology
000164200 650_2 $$2MeSH$$aMyeloid Cells: metabolism
000164200 650_2 $$2MeSH$$aNeovascularization, Physiologic: physiology
000164200 650_2 $$2MeSH$$aSequence Analysis, RNA
000164200 650_2 $$2MeSH$$aSingle-Cell Analysis
000164200 650_2 $$2MeSH$$aTranscription, Genetic: genetics
000164200 7001_ $$aHagemeyer, Nora$$b1
000164200 7001_ $$aSankowski, Roman$$b2
000164200 7001_ $$00000-0003-3336-9982$$aSchlecht, Anja$$b3
000164200 7001_ $$aStaszewski, Ori$$b4
000164200 7001_ $$aAmann, Lukas$$b5
000164200 7001_ $$aGruber, Markus$$b6
000164200 7001_ $$aKoch, Jana$$b7
000164200 7001_ $$aHausmann, Annika$$b8
000164200 7001_ $$aZhang, Peipei$$b9
000164200 7001_ $$aBoneva, Stefaniya$$b10
000164200 7001_ $$aMasuda, Takahiro$$b11
000164200 7001_ $$00000-0002-0024-1643$$aHilgendorf, Ingo$$b12
000164200 7001_ $$aGoldmann, Tobias$$b13
000164200 7001_ $$0P:(DE-2719)9000034$$aBöttcher, Chotima$$b14$$udzne
000164200 7001_ $$0P:(DE-2719)2811122$$aPriller, Josef$$b15$$udzne
000164200 7001_ $$aRossi, Fabio Mv$$b16
000164200 7001_ $$00000-0002-2580-6823$$aLange, Clemens$$b17
000164200 7001_ $$00000-0002-0349-1955$$aPrinz, Marco$$b18
000164200 773__ $$0PERI:(DE-600)1467419-1$$a10.15252/embj.2020105123$$gVol. 40, no. 6$$n6$$pe105123$$tThe EMBO journal$$v40$$x0261-4189$$y2021
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