% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Wieghofer:164200,
      author       = {Wieghofer, Peter and Hagemeyer, Nora and Sankowski, Roman
                      and Schlecht, Anja and Staszewski, Ori and Amann, Lukas and
                      Gruber, Markus and Koch, Jana and Hausmann, Annika and
                      Zhang, Peipei and Boneva, Stefaniya and Masuda, Takahiro and
                      Hilgendorf, Ingo and Goldmann, Tobias and Böttcher, Chotima
                      and Priller, Josef and Rossi, Fabio Mv and Lange, Clemens
                      and Prinz, Marco},
      title        = {{M}apping the origin and fate of myeloid cells in distinct
                      compartments of the eye by single-cell profiling.},
      journal      = {The EMBO journal},
      volume       = {40},
      number       = {6},
      issn         = {0261-4189},
      address      = {Hoboken, NJ [u.a.]},
      publisher    = {Wiley},
      reportid     = {DZNE-2022-00856},
      pages        = {e105123},
      year         = {2021},
      abstract     = {Similar to the brain, the eye is considered an
                      immune-privileged organ where tissue-resident macrophages
                      provide the major immune cell constituents. However, little
                      is known about spatially restricted macrophage subsets
                      within different eye compartments with regard to their
                      origin, function, and fate during health and disease. Here,
                      we combined single-cell analysis, fate mapping, parabiosis,
                      and computational modeling to comprehensively examine
                      myeloid subsets in distinct parts of the eye during
                      homeostasis. This approach allowed us to identify myeloid
                      subsets displaying diverse transcriptional states. During
                      choroidal neovascularization, a typical hallmark of
                      neovascular age-related macular degeneration (AMD), we
                      recognized disease-specific macrophage subpopulations with
                      distinct molecular signatures. Our results highlight the
                      heterogeneity of myeloid subsets and their dynamics in the
                      eye that provide new insights into the innate immune system
                      in this organ which may offer new therapeutic targets for
                      ophthalmological diseases.},
      keywords     = {Animals / Choroid: blood supply / Choroid: embryology /
                      Computational Biology / Computer Simulation / Eye: cytology
                      / Eye: immunology / Eye: metabolism / Female / Homeostasis:
                      immunology / Humans / Immunity, Innate: immunology /
                      Macrophages: immunology / Macular Degeneration: pathology /
                      Male / Mice / Mice, Inbred C57BL / Mice, Transgenic /
                      Microglia: physiology / Myeloid Cells: immunology / Myeloid
                      Cells: metabolism / Neovascularization, Physiologic:
                      physiology / Sequence Analysis, RNA / Single-Cell Analysis /
                      Transcription, Genetic: genetics / cornea (Other) /
                      macrophages (Other) / microglia (Other) / retina (Other) /
                      single-cell RNA-seq (Other)},
      cin          = {AG Priller},
      ddc          = {570},
      cid          = {I:(DE-2719)5000007},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33555074},
      pmc          = {pmc:PMC7957431},
      doi          = {10.15252/embj.2020105123},
      url          = {https://pub.dzne.de/record/164200},
}