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001     164200
005     20240619121039.0
024 7 _ |a 10.15252/embj.2020105123
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037 _ _ |a DZNE-2022-00856
041 _ _ |a English
082 _ _ |a 570
100 1 _ |a Wieghofer, Peter
|0 P:(DE-2719)9000347
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|u dzne
245 _ _ |a Mapping the origin and fate of myeloid cells in distinct compartments of the eye by single-cell profiling.
260 _ _ |a Hoboken, NJ [u.a.]
|c 2021
|b Wiley
336 7 _ |a article
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520 _ _ |a Similar to the brain, the eye is considered an immune-privileged organ where tissue-resident macrophages provide the major immune cell constituents. However, little is known about spatially restricted macrophage subsets within different eye compartments with regard to their origin, function, and fate during health and disease. Here, we combined single-cell analysis, fate mapping, parabiosis, and computational modeling to comprehensively examine myeloid subsets in distinct parts of the eye during homeostasis. This approach allowed us to identify myeloid subsets displaying diverse transcriptional states. During choroidal neovascularization, a typical hallmark of neovascular age-related macular degeneration (AMD), we recognized disease-specific macrophage subpopulations with distinct molecular signatures. Our results highlight the heterogeneity of myeloid subsets and their dynamics in the eye that provide new insights into the innate immune system in this organ which may offer new therapeutic targets for ophthalmological diseases.
536 _ _ |a 353 - Clinical and Health Care Research (POF4-353)
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650 _ 7 |a cornea
|2 Other
650 _ 7 |a macrophages
|2 Other
650 _ 7 |a microglia
|2 Other
650 _ 7 |a retina
|2 Other
650 _ 7 |a single-cell RNA-seq
|2 Other
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Choroid: blood supply
|2 MeSH
650 _ 2 |a Choroid: embryology
|2 MeSH
650 _ 2 |a Computational Biology
|2 MeSH
650 _ 2 |a Computer Simulation
|2 MeSH
650 _ 2 |a Eye: cytology
|2 MeSH
650 _ 2 |a Eye: immunology
|2 MeSH
650 _ 2 |a Eye: metabolism
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Homeostasis: immunology
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Immunity, Innate: immunology
|2 MeSH
650 _ 2 |a Macrophages: immunology
|2 MeSH
650 _ 2 |a Macular Degeneration: pathology
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Mice
|2 MeSH
650 _ 2 |a Mice, Inbred C57BL
|2 MeSH
650 _ 2 |a Mice, Transgenic
|2 MeSH
650 _ 2 |a Microglia: physiology
|2 MeSH
650 _ 2 |a Myeloid Cells: immunology
|2 MeSH
650 _ 2 |a Myeloid Cells: metabolism
|2 MeSH
650 _ 2 |a Neovascularization, Physiologic: physiology
|2 MeSH
650 _ 2 |a Sequence Analysis, RNA
|2 MeSH
650 _ 2 |a Single-Cell Analysis
|2 MeSH
650 _ 2 |a Transcription, Genetic: genetics
|2 MeSH
700 1 _ |a Hagemeyer, Nora
|b 1
700 1 _ |a Sankowski, Roman
|b 2
700 1 _ |a Schlecht, Anja
|0 0000-0003-3336-9982
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700 1 _ |a Staszewski, Ori
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700 1 _ |a Amann, Lukas
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700 1 _ |a Gruber, Markus
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700 1 _ |a Koch, Jana
|b 7
700 1 _ |a Hausmann, Annika
|b 8
700 1 _ |a Zhang, Peipei
|b 9
700 1 _ |a Boneva, Stefaniya
|b 10
700 1 _ |a Masuda, Takahiro
|b 11
700 1 _ |a Hilgendorf, Ingo
|0 0000-0002-0024-1643
|b 12
700 1 _ |a Goldmann, Tobias
|b 13
700 1 _ |a Böttcher, Chotima
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700 1 _ |a Priller, Josef
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700 1 _ |a Rossi, Fabio Mv
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700 1 _ |a Lange, Clemens
|0 0000-0002-2580-6823
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700 1 _ |a Prinz, Marco
|0 0000-0002-0349-1955
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773 _ _ |a 10.15252/embj.2020105123
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856 4 _ |y OpenAccess
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