%0 Journal Article
%A Zebhauser, Paul Theo
%A Berthele, Achim
%A Franz, Marie-Sophie
%A Goldhardt, Oliver
%A Diehl-Schmid, Janine
%A Priller, Josef
%A Ortner, Marion
%A Grimmer, Timo
%T Age-Dependency of Total Tau in the Cerebrospinal Fluid Is Corrected by Amyloid-β 1-40: A Correlational Study in Healthy Adults.
%J Journal of Alzheimer's disease
%V 83
%N 1
%@ 1387-2877
%C Amsterdam
%I IOS Press
%M DZNE-2022-00858
%P 155 - 162
%D 2021
%X Tau proteins are established biomarkers of neuroaxonal damage in a wide range of neurodegenerative conditions. Although measurement of total-Tau in the cerebrospinal fluid is widely used in research and clinical settings, the relationship between age and total-Tau in the cerebrospinal fluid is yet to be fully understood. While past studies reported a correlation between age and total-Tau in the cerebrospinal fluid of healthy adults, in clinical practice the same cut-off value is used independently of patient's age.To further explore the relationship between age and total-Tau and to disentangle neurodegenerative from drainage-dependent effects.We analyzed cerebrospinal fluid samples of 76 carefully selected cognitively healthy adults and included amyloid-β 1-40 as a potential marker of drainage from the brain's interstitial system.We found a significant correlation of total-Tau and age, which was no longer present when correcting total-Tau for amyloid-β 1-40 concentrations. These findings were replicated under varied inclusion criteria.Results call into question the association of age and total-Tau in the cerebrospinal fluid. Furthermore, they suggest diagnostic utility of amyloid-β 1-40 as a possible proxy for drainage-mechanisms into the cerebrospinal fluid when interpreting biomarker concentrations for neurodegenerative diseases.
%K Age Factors
%K Amyloid beta-Peptides: cerebrospinal fluid
%K Biomarkers: cerebrospinal fluid
%K Female
%K Healthy Volunteers: statistics & numerical data
%K Humans
%K Male
%K Middle Aged
%K Models, Statistical
%K Peptide Fragments: cerebrospinal fluid
%K tau Proteins: cerebrospinal fluid
%K Alzheimer’s disease (Other)
%K amyloid-beta 1–40 (Other)
%K tau proteins (Other)
%K total-Tau (Other)
%K Amyloid beta-Peptides (NLM Chemicals)
%K Biomarkers (NLM Chemicals)
%K Peptide Fragments (NLM Chemicals)
%K amyloid beta-protein (1-40) (NLM Chemicals)
%K tau Proteins (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:34250938
%R 10.3233/JAD-210286
%U https://pub.dzne.de/record/164202