Journal Article

DZNE-2022-00858

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Age-Dependency of Total Tau in the Cerebrospinal Fluid Is Corrected by Amyloid-β 1-40: A Correlational Study in Healthy Adults.

Zebhauser, P. T. ; Berthele, A. ; Franz, M.-S. ; Goldhardt, O. ; Diehl-Schmid, J.Extern* ; Priller, J.DZNE* ; Ortner, M. ; Grimmer, T.

2021
IOS Press Amsterdam

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Please use a persistent id in citations: doi:10.3233/JAD-210286

Abstract: Tau proteins are established biomarkers of neuroaxonal damage in a wide range of neurodegenerative conditions. Although measurement of total-Tau in the cerebrospinal fluid is widely used in research and clinical settings, the relationship between age and total-Tau in the cerebrospinal fluid is yet to be fully understood. While past studies reported a correlation between age and total-Tau in the cerebrospinal fluid of healthy adults, in clinical practice the same cut-off value is used independently of patient's age.To further explore the relationship between age and total-Tau and to disentangle neurodegenerative from drainage-dependent effects.We analyzed cerebrospinal fluid samples of 76 carefully selected cognitively healthy adults and included amyloid-β 1-40 as a potential marker of drainage from the brain's interstitial system.We found a significant correlation of total-Tau and age, which was no longer present when correcting total-Tau for amyloid-β 1-40 concentrations. These findings were replicated under varied inclusion criteria.Results call into question the association of age and total-Tau in the cerebrospinal fluid. Furthermore, they suggest diagnostic utility of amyloid-β 1-40 as a possible proxy for drainage-mechanisms into the cerebrospinal fluid when interpreting biomarker concentrations for neurodegenerative diseases.

Keyword(s): Age Factors (MeSH) ; Amyloid beta-Peptides: cerebrospinal fluid (MeSH) ; Biomarkers: cerebrospinal fluid (MeSH) ; Female (MeSH) ; Healthy Volunteers: statistics & numerical data (MeSH) ; Humans (MeSH) ; Male (MeSH) ; Middle Aged (MeSH) ; Models, Statistical (MeSH) ; Peptide Fragments: cerebrospinal fluid (MeSH) ; tau Proteins: cerebrospinal fluid (MeSH) ; Alzheimer’s disease ; amyloid-beta 1–40 ; tau proteins ; total-Tau ; Amyloid beta-Peptides ; Biomarkers ; Peptide Fragments ; amyloid beta-protein (1-40) ; tau Proteins

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Contributing Institute(s):

1. Translational Neuropsychiatry (AG Priller)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2021

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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