TY  - JOUR
AU  - Zebhauser, Paul Theo
AU  - Berthele, Achim
AU  - Franz, Marie-Sophie
AU  - Goldhardt, Oliver
AU  - Diehl-Schmid, Janine
AU  - Priller, Josef
AU  - Ortner, Marion
AU  - Grimmer, Timo
TI  - Age-Dependency of Total Tau in the Cerebrospinal Fluid Is Corrected by Amyloid-β 1-40: A Correlational Study in Healthy Adults.
JO  - Journal of Alzheimer's disease
VL  - 83
IS  - 1
SN  - 1387-2877
CY  - Amsterdam
PB  - IOS Press
M1  - DZNE-2022-00858
SP  - 155 - 162
PY  - 2021
AB  - Tau proteins are established biomarkers of neuroaxonal damage in a wide range of neurodegenerative conditions. Although measurement of total-Tau in the cerebrospinal fluid is widely used in research and clinical settings, the relationship between age and total-Tau in the cerebrospinal fluid is yet to be fully understood. While past studies reported a correlation between age and total-Tau in the cerebrospinal fluid of healthy adults, in clinical practice the same cut-off value is used independently of patient's age.To further explore the relationship between age and total-Tau and to disentangle neurodegenerative from drainage-dependent effects.We analyzed cerebrospinal fluid samples of 76 carefully selected cognitively healthy adults and included amyloid-β 1-40 as a potential marker of drainage from the brain's interstitial system.We found a significant correlation of total-Tau and age, which was no longer present when correcting total-Tau for amyloid-β 1-40 concentrations. These findings were replicated under varied inclusion criteria.Results call into question the association of age and total-Tau in the cerebrospinal fluid. Furthermore, they suggest diagnostic utility of amyloid-β 1-40 as a possible proxy for drainage-mechanisms into the cerebrospinal fluid when interpreting biomarker concentrations for neurodegenerative diseases.
KW  - Age Factors
KW  - Amyloid beta-Peptides: cerebrospinal fluid
KW  - Biomarkers: cerebrospinal fluid
KW  - Female
KW  - Healthy Volunteers: statistics & numerical data
KW  - Humans
KW  - Male
KW  - Middle Aged
KW  - Models, Statistical
KW  - Peptide Fragments: cerebrospinal fluid
KW  - tau Proteins: cerebrospinal fluid
KW  - Alzheimer’s disease (Other)
KW  - amyloid-beta 1–40 (Other)
KW  - tau proteins (Other)
KW  - total-Tau (Other)
KW  - Amyloid beta-Peptides (NLM Chemicals)
KW  - Biomarkers (NLM Chemicals)
KW  - Peptide Fragments (NLM Chemicals)
KW  - amyloid beta-protein (1-40) (NLM Chemicals)
KW  - tau Proteins (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:34250938
DO  - DOI:10.3233/JAD-210286
UR  - https://pub.dzne.de/record/164202
ER  -