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@ARTICLE{Zebhauser:164202,
      author       = {Zebhauser, Paul Theo and Berthele, Achim and Franz,
                      Marie-Sophie and Goldhardt, Oliver and Diehl-Schmid, Janine
                      and Priller, Josef and Ortner, Marion and Grimmer, Timo},
      title        = {{A}ge-{D}ependency of {T}otal {T}au in the {C}erebrospinal
                      {F}luid {I}s {C}orrected by {A}myloid-β 1-40: {A}
                      {C}orrelational {S}tudy in {H}ealthy {A}dults.},
      journal      = {Journal of Alzheimer's disease},
      volume       = {83},
      number       = {1},
      issn         = {1387-2877},
      address      = {Amsterdam},
      publisher    = {IOS Press},
      reportid     = {DZNE-2022-00858},
      pages        = {155 - 162},
      year         = {2021},
      abstract     = {Tau proteins are established biomarkers of neuroaxonal
                      damage in a wide range of neurodegenerative conditions.
                      Although measurement of total-Tau in the cerebrospinal fluid
                      is widely used in research and clinical settings, the
                      relationship between age and total-Tau in the cerebrospinal
                      fluid is yet to be fully understood. While past studies
                      reported a correlation between age and total-Tau in the
                      cerebrospinal fluid of healthy adults, in clinical practice
                      the same cut-off value is used independently of patient's
                      age.To further explore the relationship between age and
                      total-Tau and to disentangle neurodegenerative from
                      drainage-dependent effects.We analyzed cerebrospinal fluid
                      samples of 76 carefully selected cognitively healthy adults
                      and included amyloid-β 1-40 as a potential marker of
                      drainage from the brain's interstitial system.We found a
                      significant correlation of total-Tau and age, which was no
                      longer present when correcting total-Tau for amyloid-β 1-40
                      concentrations. These findings were replicated under varied
                      inclusion criteria.Results call into question the
                      association of age and total-Tau in the cerebrospinal fluid.
                      Furthermore, they suggest diagnostic utility of amyloid-β
                      1-40 as a possible proxy for drainage-mechanisms into the
                      cerebrospinal fluid when interpreting biomarker
                      concentrations for neurodegenerative diseases.},
      keywords     = {Age Factors / Amyloid beta-Peptides: cerebrospinal fluid /
                      Biomarkers: cerebrospinal fluid / Female / Healthy
                      Volunteers: statistics $\&$ numerical data / Humans / Male /
                      Middle Aged / Models, Statistical / Peptide Fragments:
                      cerebrospinal fluid / tau Proteins: cerebrospinal fluid /
                      Alzheimer’s disease (Other) / amyloid-beta 1–40 (Other)
                      / tau proteins (Other) / total-Tau (Other) / Amyloid
                      beta-Peptides (NLM Chemicals) / Biomarkers (NLM Chemicals) /
                      Peptide Fragments (NLM Chemicals) / amyloid beta-protein
                      (1-40) (NLM Chemicals) / tau Proteins (NLM Chemicals)},
      cin          = {AG Priller},
      ddc          = {610},
      cid          = {I:(DE-2719)5000007},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34250938},
      doi          = {10.3233/JAD-210286},
      url          = {https://pub.dzne.de/record/164202},
}