TY  - JOUR
AU  - Hallab, Asma
AU  - Lange, Catharina
AU  - Apostolova, Ivayla
AU  - Özden, Cansu
AU  - Gonzalez Escamilla, Gabriel
AU  - Klutmann, Susanne
AU  - Brenner, Winfried
AU  - Grothe, Michel J
AU  - Buchert, Ralph
TI  - Impairment of Everyday Spatial Navigation Abilities in Mild Cognitive Impairment Is Weakly Associated with Reduced Grey Matter Volume in the Medial Part of the Entorhinal Cortex.
JO  - Journal of Alzheimer's disease
VL  - 78
IS  - 3
SN  - 1387-2877
CY  - Amsterdam
PB  - IOS Press
M1  - DZNE-2022-01007
SP  - 1149 - 1159
PY  - 2020
AB  - Research in rodents identified specific neuron populations encoding information for spatial navigation with particularly high density in the medial part of the entorhinal cortex (ERC), which may be homologous with Brodmann area 34 (BA34) in the human brain.The aim of this study was to test whether impaired spatial navigation frequently occurring in mild cognitive impairment (MCI) is specifically associated with neurodegeneration in BA34.The study included baseline data of MCI patients enrolled in the Alzheimer's Disease Neuroimaging Initiative with high-resolution structural MRI, brain FDG PET, and complete visuospatial ability scores of the Everyday Cognition test (VS-ECog) within 30 days of PET. A standard mask of BA34 predefined in MNI space was mapped to individual native space to determine grey matter volume and metabolic activity in BA34 on MRI and on (partial volume corrected) FDG PET, respectively. The association of the VS-ECog sum score with grey matter volume and metabolic activity in BA34, APOE4 carrier status, age, education, and global cognition (ADAS-cog-13 score) was tested by linear regression. BA28, which constitutes the lateral part of the ERC, was used as control region.The eligibility criteria led to inclusion of 379 MCI subjects. The VS-ECog sum score was negatively correlated with grey matter volume in BA34 (β= -0.229, p = 0.022) and age (β= -0.124, p = 0.036), and was positively correlated with ADAS-cog-13 (β= 0.175, p = 0.003). None of the other predictor variables contributed significantly.Impairment of spatial navigation in MCI is weakly associated with BA34 atrophy.
KW  - Activities of Daily Living
KW  - Aged
KW  - Aged, 80 and over
KW  - Atrophy
KW  - Cognitive Dysfunction: diagnostic imaging
KW  - Cognitive Dysfunction: pathology
KW  - Cognitive Dysfunction: physiopathology
KW  - Entorhinal Cortex: diagnostic imaging
KW  - Entorhinal Cortex: pathology
KW  - Female
KW  - Fluorodeoxyglucose F18
KW  - Gray Matter: diagnostic imaging
KW  - Gray Matter: pathology
KW  - Humans
KW  - Magnetic Resonance Imaging
KW  - Male
KW  - Middle Aged
KW  - Organ Size
KW  - Positron-Emission Tomography
KW  - Radiopharmaceuticals
KW  - Spatial Navigation: physiology
KW  - 18F-fluorodeoxyglucose (Other)
KW  - Entorhinal cortex (Other)
KW  - grid cells (Other)
KW  - magnetic resonance imaging (Other)
KW  - mild cognitive impairment (Other)
KW  - positron emission tomography (Other)
KW  - spatial navigation (Other)
KW  - volumetry (Other)
KW  - Radiopharmaceuticals (NLM Chemicals)
KW  - Fluorodeoxyglucose F18 (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:33104026
DO  - DOI:10.3233/JAD-200520
UR  - https://pub.dzne.de/record/164455
ER  -