Journal Article

DZNE-2022-01007

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Impairment of Everyday Spatial Navigation Abilities in Mild Cognitive Impairment Is Weakly Associated with Reduced Grey Matter Volume in the Medial Part of the Entorhinal Cortex.

Hallab, A. ; Lange, C.Extern* ; Apostolova, I. ; Özden, C. ; Gonzalez Escamilla, G.DZNE* ; Klutmann, S. ; Brenner, W. ; Grothe, M. J.DZNE* ; Buchert, R. ; Initiative, A. D. N. (Collaboration Author)

2020
IOS Press Amsterdam

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Please use a persistent id in citations: doi:10.3233/JAD-200520

Abstract: Research in rodents identified specific neuron populations encoding information for spatial navigation with particularly high density in the medial part of the entorhinal cortex (ERC), which may be homologous with Brodmann area 34 (BA34) in the human brain.The aim of this study was to test whether impaired spatial navigation frequently occurring in mild cognitive impairment (MCI) is specifically associated with neurodegeneration in BA34.The study included baseline data of MCI patients enrolled in the Alzheimer's Disease Neuroimaging Initiative with high-resolution structural MRI, brain FDG PET, and complete visuospatial ability scores of the Everyday Cognition test (VS-ECog) within 30 days of PET. A standard mask of BA34 predefined in MNI space was mapped to individual native space to determine grey matter volume and metabolic activity in BA34 on MRI and on (partial volume corrected) FDG PET, respectively. The association of the VS-ECog sum score with grey matter volume and metabolic activity in BA34, APOE4 carrier status, age, education, and global cognition (ADAS-cog-13 score) was tested by linear regression. BA28, which constitutes the lateral part of the ERC, was used as control region.The eligibility criteria led to inclusion of 379 MCI subjects. The VS-ECog sum score was negatively correlated with grey matter volume in BA34 (β= -0.229, p = 0.022) and age (β= -0.124, p = 0.036), and was positively correlated with ADAS-cog-13 (β= 0.175, p = 0.003). None of the other predictor variables contributed significantly.Impairment of spatial navigation in MCI is weakly associated with BA34 atrophy.

Keyword(s): Activities of Daily Living (MeSH) ; Aged (MeSH) ; Aged, 80 and over (MeSH) ; Atrophy (MeSH) ; Cognitive Dysfunction: diagnostic imaging (MeSH) ; Cognitive Dysfunction: pathology (MeSH) ; Cognitive Dysfunction: physiopathology (MeSH) ; Entorhinal Cortex: diagnostic imaging (MeSH) ; Entorhinal Cortex: pathology (MeSH) ; Female (MeSH) ; Fluorodeoxyglucose F18 (MeSH) ; Gray Matter: diagnostic imaging (MeSH) ; Gray Matter: pathology (MeSH) ; Humans (MeSH) ; Magnetic Resonance Imaging (MeSH) ; Male (MeSH) ; Middle Aged (MeSH) ; Organ Size (MeSH) ; Positron-Emission Tomography (MeSH) ; Radiopharmaceuticals (MeSH) ; Spatial Navigation: physiology (MeSH) ; 18F-fluorodeoxyglucose ; Entorhinal cortex ; grid cells ; magnetic resonance imaging ; mild cognitive impairment ; positron emission tomography ; spatial navigation ; volumetry ; Radiopharmaceuticals ; Fluorodeoxyglucose F18

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Contributing Institute(s):

1. Clinical Dementia Research (Rostock /Greifswald) (AG Teipel)

Research Program(s):

1. 899 - ohne Topic (POF4-899) (POF4-899)

Appears in the scientific report 2020

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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