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@ARTICLE{Hallab:164455,
      author       = {Hallab, Asma and Lange, Catharina and Apostolova, Ivayla
                      and Özden, Cansu and Gonzalez Escamilla, Gabriel and
                      Klutmann, Susanne and Brenner, Winfried and Grothe, Michel J
                      and Buchert, Ralph},
      collaboration = {Initiative, Alzheimer’s Disease Neuroimaging},
      title        = {{I}mpairment of {E}veryday {S}patial {N}avigation
                      {A}bilities in {M}ild {C}ognitive {I}mpairment {I}s {W}eakly
                      {A}ssociated with {R}educed {G}rey {M}atter {V}olume in the
                      {M}edial {P}art of the {E}ntorhinal {C}ortex.},
      journal      = {Journal of Alzheimer's disease},
      volume       = {78},
      number       = {3},
      issn         = {1387-2877},
      address      = {Amsterdam},
      publisher    = {IOS Press},
      reportid     = {DZNE-2022-01007},
      pages        = {1149 - 1159},
      year         = {2020},
      abstract     = {Research in rodents identified specific neuron populations
                      encoding information for spatial navigation with
                      particularly high density in the medial part of the
                      entorhinal cortex (ERC), which may be homologous with
                      Brodmann area 34 (BA34) in the human brain.The aim of this
                      study was to test whether impaired spatial navigation
                      frequently occurring in mild cognitive impairment (MCI) is
                      specifically associated with neurodegeneration in BA34.The
                      study included baseline data of MCI patients enrolled in the
                      Alzheimer's Disease Neuroimaging Initiative with
                      high-resolution structural MRI, brain FDG PET, and complete
                      visuospatial ability scores of the Everyday Cognition test
                      (VS-ECog) within 30 days of PET. A standard mask of BA34
                      predefined in MNI space was mapped to individual native
                      space to determine grey matter volume and metabolic activity
                      in BA34 on MRI and on (partial volume corrected) FDG PET,
                      respectively. The association of the VS-ECog sum score with
                      grey matter volume and metabolic activity in BA34, APOE4
                      carrier status, age, education, and global cognition
                      (ADAS-cog-13 score) was tested by linear regression. BA28,
                      which constitutes the lateral part of the ERC, was used as
                      control region.The eligibility criteria led to inclusion of
                      379 MCI subjects. The VS-ECog sum score was negatively
                      correlated with grey matter volume in BA34 (β= -0.229, p =
                      0.022) and age (β= -0.124, p = 0.036), and was positively
                      correlated with ADAS-cog-13 (β= 0.175, p = 0.003). None of
                      the other predictor variables contributed
                      significantly.Impairment of spatial navigation in MCI is
                      weakly associated with BA34 atrophy.},
      keywords     = {Activities of Daily Living / Aged / Aged, 80 and over /
                      Atrophy / Cognitive Dysfunction: diagnostic imaging /
                      Cognitive Dysfunction: pathology / Cognitive Dysfunction:
                      physiopathology / Entorhinal Cortex: diagnostic imaging /
                      Entorhinal Cortex: pathology / Female / Fluorodeoxyglucose
                      F18 / Gray Matter: diagnostic imaging / Gray Matter:
                      pathology / Humans / Magnetic Resonance Imaging / Male /
                      Middle Aged / Organ Size / Positron-Emission Tomography /
                      Radiopharmaceuticals / Spatial Navigation: physiology /
                      18F-fluorodeoxyglucose (Other) / Entorhinal cortex (Other) /
                      grid cells (Other) / magnetic resonance imaging (Other) /
                      mild cognitive impairment (Other) / positron emission
                      tomography (Other) / spatial navigation (Other) / volumetry
                      (Other) / Radiopharmaceuticals (NLM Chemicals) /
                      Fluorodeoxyglucose F18 (NLM Chemicals)},
      cin          = {AG Teipel},
      ddc          = {610},
      cid          = {I:(DE-2719)1510100},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33104026},
      doi          = {10.3233/JAD-200520},
      url          = {https://pub.dzne.de/record/164455},
}