Journal Article

DZNE-2022-01010

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Pre-Analytical Sampling and Storage Conditions of Amyloid-β Peptides in Venous and Capillary Blood

Walter, M. ; Wiltfang, J.DZNE* ; Vogelgsang, J.

2020
IOS Press Amsterdam

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Please use a persistent id in citations: doi:10.3233/JAD-200777

Abstract: Previous studies on blood-based biomarkers for Alzheimer's disease suggest a less invasive blood test might be a valuable screening tool for Alzheimer-specific pathology. Pre-analytical sample storage conditions seem to play an important role on amyloid-β (Aβ) stability, impacting reliability and reproducibility. This study shows that Aβ40, Aβ42, and Aβ42/40 levels significantly and early decrease during storage at room temperature in whole blood or plasma. Storing blood samples at 4°C leads to stable Aβ peptide concentrations up to 72 h. In addition, Aβ peptides can be measured in capillary blood with a stable Aβ42/40 ratio up to 72 h at 4°C.

Keyword(s): Adult (MeSH) ; Aged (MeSH) ; Aged, 80 and over (MeSH) ; Amyloid beta-Peptides: blood (MeSH) ; Biomarkers: blood (MeSH) ; Blood Specimen Collection: methods (MeSH) ; Blood Specimen Collection: standards (MeSH) ; Blood Specimen Collection: trends (MeSH) ; Capillaries: metabolism (MeSH) ; Female (MeSH) ; Humans (MeSH) ; Male (MeSH) ; Middle Aged (MeSH) ; Pilot Projects (MeSH) ; Protein Stability (MeSH) ; Specimen Handling: methods (MeSH) ; Specimen Handling: standards (MeSH) ; Specimen Handling: trends (MeSH) ; Veins: metabolism (MeSH) ; Young Adult (MeSH)

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Contributing Institute(s):

1. Molecular biomarkers for predictive diagnostics of neurodegenerative diseases (AG Wiltfang)

Research Program(s):

1. 899 - ohne Topic (POF4-899) (POF4-899)

Appears in the scientific report 2020

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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