Journal Article (Review Article)

DZNE-2022-01371

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Optogenetics at the presynapse.

Rost, B. R. (First author)DZNE* ; Wietek, J. ; Yizhar, O. ; Schmitz, D. (Last author)DZNE*

2022
Nature America New York, NY

This record in other databases:    

Please use a persistent id in citations: doi:10.1038/s41593-022-01113-6

Abstract: Optogenetic actuators enable highly precise spatiotemporal interrogation of biological processes at levels ranging from the subcellular to cells, circuits and behaving organisms. Although their application in neuroscience has traditionally focused on the control of spiking activity at the somatodendritic level, the scope of optogenetic modulators for direct manipulation of presynaptic functions is growing. Presynaptically localized opsins combined with light stimulation at the terminals allow light-mediated neurotransmitter release, presynaptic inhibition, induction of synaptic plasticity and specific manipulation of individual components of the presynaptic machinery. Here, we describe presynaptic applications of optogenetic tools in the context of the unique cell biology of axonal terminals, discuss their potential shortcomings and outline future directions for this rapidly developing research area.

Keyword(s): Neuronal Plasticity (MeSH) ; Opsins: genetics (MeSH) ; Optogenetics (MeSH) ; Presynaptic Terminals (MeSH) ; Synaptic Transmission: physiology (MeSH) ; Opsins

---

Contributing Institute(s):

1. Network Dysfunction (AG Schmitz)

Research Program(s):

1. 351 - Brain Function (POF4-351) (POF4-351)

Appears in the scientific report 2022

---

Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 25 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

---